In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(III) complex [Ir(L)(L′)]³⁺(PF₆⁻)₃ (C1) with L and L′ being terpyridine ligands (L = 4′-phenyl-2,2′:6′,2′′-terpyridine, L′ = 3-([2,2′:6′,2′′-terpyridin]-4′-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(III) complex [Ir(dfppy)₂CN₂]⁻Bu₄N⁺ (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes. Furthermore, this novel photosensitizer was successfully applied in photodynamic therapy (PDT) of cancer cells for the first time.

中文翻译：

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通过在两种离子金属配合物之间进行有效的能量转移，增强了软盐的单线态氧生成†

在这项研究中，基于软盐复合物的光敏剂已被开发用于癌细胞的光动力疗法（PDT）。铱（III）配合物[Ir（L）（L'）] ³⁺（PF ₆ ^- ）₃（C1）与L和L'是配位体三联吡啶（L = 4'-苯基-2,2'：6' ，2''-吡啶，L'= 3-（[[2,2'：6'，2''-terpyridin] -4'-yl）-9-hexyl-9 H-咔唑）被选作阳离子组分和铱（III）配合物[Ir（dfppy）₂ CN ₂ ] ^-卜₄ ñ ⁺（A1）作为阴离子成分。配合物C1和通过静电相互作用将A1直接连接以形成基于软盐的光敏剂（S1），由于两种离子金属配合物之间的有效能量转移，其显示出提高的单线态氧产生速率。此外，这种新型的光敏剂首次成功地用于癌细胞的光动力疗法（PDT）中。