Herein, poly(pyrrole-3-carboxylic acid) (PPyCOOH) nanoneedles with abundant carboxyl groups were synthesized by aqueous dispersion polymerization method using pyrrole-3-carboxylic acid as conductive polymer monomer. The PPyCOOH nanoneedles not only owned good photothermal performance, but also more importantly showed enhanced tumor cell uptake efficiency (1.64 fold) compared with size and zeta-potential matched nanospheres. After loading photosensitizer aluminum phthalocyanine tetrasulfonate (AlPCS₄) and modifying with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) onto the PPyCOOH nanoneedles, novel nanoneedle complexes (AlPCS₄@PPyCONH-PAH-PAA) integrating photodynamic therapy (PDT) and photothermal therapy (PTT) were successfully fabricated. The as-prepared nanoneedle complexes improved uptake efficiency of AlPCS₄ both in vitro and in vivo. Moreover, the nanoneedle complexes have infrared thermal and fluorescent properties. By combined PDT/PTT under the guiding of dual modal imaging, the tumors in mice were completely eliminated and no recurrence was observed in 30 days after treatment, indicating that PPyCOOH nanoneedles have great potential as a novel drug carrier for constructing multifunctional nanoplatform used for cancer treatment.

在此，以吡咯-3-羧酸为导电性高分子单体，通过水分散聚合法合成了羧基丰富的聚（吡咯-3-羧酸）（PPyCOOH）纳米针。PPyCOOH纳米针不仅具有良好的光热性能，而且与尺寸和Zeta电位匹配的纳米球相比，还具有更高的肿瘤细胞摄取效率（1.64倍）。将光敏剂酞菁铝四磺酸盐（AlPCS ₄）装入并用聚烯丙胺盐酸盐（PAH）和聚丙烯酸（PAA）修饰到PPyCOOH纳米针上后，得到新型纳米针络合物（AlPCS ₄成功地制造了将光动力疗法（PDT）和光热疗法（PTT）相结合的@ PPyCONH-PAH-PAA。所制备的纳米针复合物在体外和体内均可改善AlPCS _4的吸收效率。此外，纳米针络合物具有红外热和荧光性质。在双模式成像的指导下，通过PDT / PTT的组合，小鼠的肿瘤被完全消除，治疗后30天未见复发，这表明PPyCOOH纳米针作为构建新型的用于癌症的多功能纳米平台的新型药物载体具有巨大的潜力。治疗。