Coenzyme Q10 (coQ10) is a lipid-soluble antioxidant naturally present in all human cells, which plays a fundamental role during aerobic cellular respiration. The objective of this study was to investigate the solubility of coQ10 in supercritical carbon dioxide (SC-CO₂) using a dynamic semi-continuous process at different conditions of pressure (10.0 to 30.0 MPa), temperature (32 °C to 50 °C) and addition of co-solvent (ethanol at 5 and 10 mol%) for potential scale up. Melting point depression of coQ10 in SC-CO₂ decreased from 51.3 °C at ambient pressure to 32.6 °C after saturation with CO₂ at 8.0 MPa. As expected, coQ10 solubility in SC-CO₂ increased with CO₂ density, from 6.5 × 10⁻⁶ g/g_CO2 at 628.61 kg/m³ to 3.4 × 10⁻³ g/g_CO2 at 909.89 kg/m³. The addition of 10 mol% of ethanol increased the solubility up to 7.8 × 10⁻³ g/g_CO2. Better understanding of the coQ10 solubility behavior in SC-CO₂ presents potential for developing novel processes for the production of ingredients for functional foods and natural health products.

辅酶Q10（coQ10）是天然存在于所有人类细胞中的脂溶性抗氧化剂，在有氧细胞呼吸过程中起着基本作用。这项研究的目的是在不同的压力（10.0至30.0 MPa），温度（32°C至50°C）条件下使用动态半连续过程研究coQ10在超临界二氧化碳（SC-CO ₂）中的溶解度）和助溶剂（5和10 mol％的乙醇）的添加以可能扩大规模。在8.0 MPa中被CO ₂饱和后，SC-CO _2中的coQ10的熔点降低从环境压力下的51.3°C降至32.6°C 。正如预期的那样，coQ10在SC-CO _2中的溶解度随CO ₂密度的增加而从6.5×10 ^-6增加克/克_{CO 2}在628.61公斤/米³至3.4×10 ^-3 克/克_{CO 2}在909.89公斤/米³。添加10mol％的乙醇将溶解度提高至7.8×10 ^-3  g / g _{CO 2}。更好地了解coQ10在SC-CO _2中的溶解性行为，为开发用于生产功能性食品和天然保健品成分的新型工艺提供了潜力。