Carbamate esters represent an important class of compounds showing a wide range of interesting biological properties. Such compounds exhibit anti-cancer, anti-HIV, anticonvulsant, antiretroviral, anti-nociceptive, anti-inflammatory, anti-Alzheimer, and antibiotic properties. Moreover, these compounds have many applications in the area of synthetic organic chemistry. Consequently, considerable efforts have devoted to the development of efficient and practical synthetic routes to these useful compounds. However, common preparations leading to these target compounds are limited by requiring toxic reagents such as phosgene, its derivatives, or isocyanates. Synthesis of titled compounds employing CO₂ as a clean and safe carbonyl reagent in place of toxic phosgene or isocyanates has attracted considerable attention in recent years. In this mini-review we will highlight the most important developments on the synthesis of carbamate esters through the carboxylative coupling of amines with alkyl halides and CO₂ by hoping that it will stimulate researchers to develop new and improved methods for the synthesis of these biologically and synthetically important compounds with sustainable chemistry and Green Chemistry perspectives.

氨基甲酸酯代表一类重要的化合物，显示出广泛的令人感兴趣的生物学特性。这样的化合物表现出抗癌，抗HIV，抗惊厥，抗逆转录病毒，抗伤害，抗炎，抗阿尔茨海默氏症和抗生素特性。而且，这些化合物在合成有机化学领域中具有许多应用。因此，为开发这些有用的化合物的有效和实用的合成途径投入了大量的精力。但是，导致产生这些目标化合物的常规制剂受到需要毒性试剂（例如光气，其衍生物或异氰酸酯）的限制。利用CO ₂合成标题化合物近年来，作为一种有毒光气或异氰酸酯的清洁，安全的羰基试剂，备受关注。在本微型综述中，我们将重点介绍胺与烷基卤化物和CO ₂的羧基偶联，通过氨基甲酸酯的羧化偶联合成氨基甲酸酯的最重要进展，希望这将刺激研究人员开发出新的改进的方法，以生物学方式合成这些化合物。具有可持续化学和绿色化学观点的合成上重要的化合物。