To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of horizontal rotation. Behavioral and theoretical experiments indicate that these inputs, distributed over a network of 100 L6 neurons, provide both a reliable estimate and, therefore, physiological separation of head-velocity signals. During head rotation in the presence of visual stimuli, L6 neurons exhibit postsynaptic responses that approximate the arithmetic sum of the vestibular and visual-motion response. Functional input mapping reveals that these internal motion signals arrive into L6 via a direct projection from the retrosplenial cortex. We therefore propose that visual-motion processing in V1 L6 is multisensory and contextually dependent on the motion status of the animal's head.

中文翻译：

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用于整合小鼠初级视觉皮层第 6 层头部和视觉运动信号的电路。

为了解释视觉运动事件，底层计算必须涉及对观察者头部运动状态的内部参考。我们在此表明​​，小鼠初级视觉皮层 (V1) 中的第 6 层 (L6) 主要神经元接收扩散的、前庭介导的突触输入，该输入发出水平旋转角速度的信号。行为和理论实验表明，这些分布在 100 个 L6 神经元网络上的输入既提供了可靠的估计，也提供了头部速度信号的生理分离。在视觉刺激存在的头部旋转过程中，L6 神经元表现出突触后反应，近似于前庭反应和视觉运动反应的算术和。功能输入映射显示这些内部运动信号通过压后皮层的直接投射到达 L6。因此，我们认为 V1 L6 中的视觉运动处理是多感官的，并且上下文依赖于动物头部的运动状态。