Advances in the understanding of the complexities of the Wnt signaling pathway during development and tissue homeostasis have made the Wnt pathway one of the prime candidates for translational applications during tissue regeneration. Wnts are key components of the stem cell niche and are short range signaling molecules responsible for cellular decisions such as proliferation and differentiation. Systemic treatment using biologics targeting the Wnt signaling pathway have shown promising early results and will likely enter the clinical arena in the near future. This comprehensive review summarizes the intricacies how Wnts function in the context of the bone regeneration.

中文翻译：

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Wnt信号传递和骨骼再生：不能缺少一个。

对Wnt信号通路在发育和组织稳态过程中的复杂性的理解的进步使Wnt途径成为组织再生过程中翻译应用的主要候选者之一。Wnt是干细胞生态位的关键组成部分，是负责细胞决策（例如增殖和分化）的短程信号分子。使用针对Wnt信号通路的生物制剂进行的全身治疗已显示出令人鼓舞的早期结果，并且可能会在不久的将来进入临床领域。这份全面的综述总结了Wnts在骨骼再生过程中如何发挥作用的复杂性。