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Gastrin-Releasing Peptide Receptor- and Prostate-Specific Membrane Antigen-Specific Ultrasmall Gold Nanoparticles for Characterization and Diagnosis of Prostate Carcinoma via Fluorescence Imaging
Bioconjugate Chemistry ( IF 4.7 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00067
Marc Pretze , Andreas Hien 1 , Matthias Rädle 1 , Ralf Schirrmacher 2 , Carmen Wängler , Björn Wängler
Affiliation  

Gold nanoparticles (AuNPs) have widely been used for 70 years in cancer treatment, but only in the last 15 years has the focus been on specific AuNPs with homogeneous size and shape for various areas in science. They constitute a perfect platform for multifunctionalization and therefore enable the enhancement of target affinity. Here we report on the development of tumor specific AuNPs as diagnostic tools intended for the detection of prostate cancer via fluorescence imaging and positron emission tomography (PET). The AuNPs were further evaluated in vitro and in vivo and exhibited favorable diagnostic properties concerning tumor cell uptake, biodistribution, clearance, and tumor retention.

中文翻译:

胃泌素释放肽受体和前列腺特异性膜抗原特异性超小金纳米粒子,用于通过荧光成像表征和诊断前列腺癌。

金纳米颗粒(AuNPs)在癌症治疗中已被广泛使用70年,但是直到最近15年,人们才将重点放在具有均匀大小和形状的特定AuNPs上,以用于科学的各个领域。它们构成了多功能化的理想平台,因此可以增强靶标亲和力。在这里,我们报告肿瘤特异性AuNPs作为诊断工具的发展,该诊断工具旨在通过荧光成像和正电子发射断层扫描(PET)检测前列腺癌。AuNPs进一步在体外体内进行评估并表现出与肿瘤细胞摄取,生物分布,清除率和肿瘤保留有关的良好诊断特性。
更新日期:2018-03-15
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