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Safety and Effectiveness of Short-Course AmBisome in the Treatment of Post–Kala-Azar Dermal Leishmaniasis: A Prospective Cohort Study in Bangladesh
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2018-03-15 , DOI: 10.1093/cid/ciy172
Margriet den Boer 1 , Asish Kumar Das 2 , Fatima Akhter 2 , Sakib Burza 3 , V Ramesh 4 , Be-Nazir Ahmed 5 , Eduard E Zijlstra 6 , Koert Ritmeijer 1
Affiliation  

A safe and effective short-course treatment regimen for post–kala-azar dermal leishmaniasis (PKDL) is considered essential for achieving and sustaining elimination of visceral leishmaniasis (VL) in the Indian subcontinent [1, 2]. Here, single-dose liposomal amphotericin B (AmBisome) has been adopted as a first-line regimen for VL; however the effectiveness and safety of AmBisome for PKDL has not been formally evaluated.

中文翻译:

短期AmBisome治疗Kala-Azar后皮肤利什曼病的安全性和有效性:孟加拉国的一项前瞻性队列研究

对于印度次大陆实现并持续消除内脏利什曼病(VL)而言,一种安全有效的短时间治疗黑热病后皮肤利什曼病(PKDL)的短程治疗方案必不可少[1,2]。在这里,单剂量脂质体两性霉素B(AmBisome)已被用作VL的一线治疗方案。但是,AmBisome对PKDL的有效性和安全性尚未得到正式评估。
更新日期:2018-03-15
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