The epidemic of obesity has led to increased risk of many types of cancer including hepatocellular carcinoma (HCC).1 HCC is the most frequent presentation of liver cancer, the fifth most common cancer in men worldwide and the seventh in women.2 Even though viral and alcohol-related liver diseases are main causes of HCC, non-alcoholic fatty liver disease (NAFLD) has become the most rapidly increasing cause during the last decade.1 Even more, HCC may also develop in the absence of liver cirrhosis, and the incidence in livers without fibrosis is higher in the metabolic syndrome and NAFLD.1 According to data from the Surveillance, Epidemiology and End Results registries (2004–2009), in the USA, NAFLD-driven HCC is associated with shorter survival time and more advanced tumour stage.3 Besides, although numerous drugs have been proposed, there is still no available treatment for most patients with HCC.4 Thus, there is a need to understand the mechanism involved in NAFLD-driven HCC to provide new targets of treatment. A hallmark of NAFLD and HCC is the disrupted lipid metabolism. Fujiwara et al 5 provide a new mechanism that links lipid accumulation with carcinogenesis in …

中文翻译：

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富含脂质的环境：促进肥胖相关非酒精性脂肪性肝病致癌的关键作用

大多数 HCC 患者仍然没有可用的治疗方法。4 因此，有必要了解 NAFLD 驱动的 HCC 所涉及的机制，以提供新的治疗目标。NAFLD 和 HCC 的一个标志是脂质代谢紊乱。Fujiwara 等人 5 提供了一种将脂质积累与癌症发生联系起来的新机制……