当前位置: X-MOL 学术Circulation › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Risk and Prognosis of Cancer After Lower Limb Arterial Thrombosis
Circulation ( IF 37.8 ) Pub Date : 2018-03-14 , DOI: 10.1161/circulationaha.117.032617
Jens Sundbøll 1 , Katalin Veres 1 , Erzsébet Horváth-Puhó 1 , Kasper Adelborg 1 , Henrik Toft Sørensen 1
Affiliation  

Background:Venous thromboembolism can be a presenting symptom of cancer, but the association between lower limb arterial thrombosis and cancer is unknown. We therefore examined cancer risk and prognosis of cancer in patients with lower limb arterial thrombosis.Methods:Using nationwide population-based Danish medical registries, we identified all patients diagnosed with first-time lower limb arterial thrombosis (1994−2013) and followed them until the occurrence of any subsequent cancer diagnosis, emigration, death, or November 30, 2013, whichever came first. We computed standardized incidence ratios with 95% confidence intervals as the observed number of cancers relative to the expected number based on national incidence rates by sex, age, and calendar year. To examine the prognostic impact of lower limb arterial thrombosis on all-cause mortality after cancer, we constructed a matched comparison cohort of patients who had cancer without lower limb arterial thrombosis.Results:Among 6600 patients with lower limb arterial thrombosis, we observed 772 subsequent cancers. The risk of any cancer was 2.5% after 6 months of follow-up, increasing to 17.9% after 20 years. During the first 6 months of follow-up, the standardized incidence ratio of any cancer was 3.28 (95% confidence interval, 2.79–3.82). The standardized incidence ratio remained elevated during 7 to 12 months (1.42; 95% confidence interval, 1.09–1.83) and beyond 12 months (1.14; 95% confidence interval, 1.05–1.24). The strongest associations were found for lung cancer and other smoking-related cancers. Lower limb arterial thrombosis also was associated with increased all-cause mortality after colon, lung, urinary bladder, and breast cancer, but not after prostate cancer.Conclusions:Lower limb arterial thrombosis was a marker of occult cancer, especially lung cancer, and was an adverse prognostic factor for mortality in common cancers.

中文翻译:

下肢动脉血栓形成后癌症的风险和预后

背景:静脉血栓栓塞可能是癌症的一种表现症状,但下肢动脉血栓形成与癌症之间的关联尚不清楚。因此,我们检查了下肢动脉血栓形成患者的癌症风险和癌症预后。方法:使用全国范围内基于人群的丹麦医学注册资料,我们确定了所有诊断为首次下肢动脉血栓形成(1994-2013)的患者,并对其进行随访直至随后发生的任何癌症诊断,移民,死亡或2013年11月30日(以先到者为准)的发生。我们根据性别,年龄和日历年的全国发病率,以95%的置信区间计算了标准化的发病率,将其作为观察到的癌症数量相对于预期的癌症数量。为了研究下肢动脉血栓形成对癌症后全因死亡率的预后影响,我们建立了一个匹配的比较队列,研究了无下肢动脉血栓形成的癌症患者。结果:在6600例下肢动脉血栓形成患者中,我们观察了772例癌症。随访6个月后,患癌症的风险为2.5%,而20年后增加到17.9%。在随访的前6个月中,任何癌症的标准发生率均为3.28(95%置信区间为2.79-3.82)。在7到12个月(1.42; 95%的置信区间,1.09-1.83)和超过12个月(1.14; 95%的置信区间,1.05-1.24)期间,标准化的发病率仍然升高。发现与肺癌和其他与吸烟有关的癌症之间的关联最强。
更新日期:2018-08-14
down
wechat
bug