Nonstructural protein σ1s is required for reovirus bloodstream dissemination. However, σ1s function in the context of reovirus replication and the mechanisms by which σ1s promotes hematogenous spread are not well understood. Phillips et al. (e02259-17) discovered that σ1s promotes optimal reovirus protein expression, which is required for efficient viral replication. This work indicates a new function for viral protein σ1s during reovirus replication and a mechanism by which σ1s facilitates hematogenous reovirus dissemination.

Nonstructural protein σ1s is required for optimal reovirus protein expression.

中文翻译：

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编辑从本期中精选的重要文章

呼肠孤病毒血流传播需要非结构蛋白σ1s。然而，σ1s在呼肠孤病毒复制的背景下发挥作用，而σ1s促进血源性扩散的机制尚不十分清楚。菲利普斯（Phillips）等人。（e02259-17）发现σ1s促进了最佳的呼肠孤病毒蛋白表达，这是有效病毒复制所必需的。这项工作表明呼肠孤病毒复制过程中病毒蛋白σ1s的新功能，以及σ1s促进血源性呼肠孤病毒传播的机制。

非结构蛋白σ1s是最佳呼肠孤病毒蛋白表达所必需的。