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Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria
Phytochemistry ( IF 3.8 ) Pub Date : 2018-06-01 , DOI: 10.1016/j.phytochem.2018.03.005
Meryem Lehbili , Abdulmagid Alabdul Magid , Ahmed Kabouche , Laurence Voutquenne-Nazabadioko , Hamid Morjani , Dominique Harakat , Zahia Kabouche

Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080). Scabiostellatoside F, a heptasaccharide derivative of oleanolic acid, exhibited moderate cytotoxicity against HT1080 cell line with IC50 value of 12.0 μM.

中文翻译:

阿尔及利亚东北部采集的星芒草中的三萜皂苷

八种未描述的三萜皂苷、scabiostellatosides AH 以及三种已知化合物从 Scabiosa stellata L 的全株中分离出来。它们的结构是通过光谱分析(1D、2D-NMR 和 HRESIMS)和化学方法确定的。评估了 Scabiostellatosides AH 对人纤维肉瘤细胞系 (HT1080) 的细胞毒性。Scabiostellatoside F 是齐墩果酸的七糖衍生物,对 HT1080 细胞系表现出中等的细胞毒性,IC50 值为 12.0 μM。
更新日期:2018-06-01
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