18-facet polyhedron Cu₇S₄ nanocrystal and CuS sphere were prepared from Cu₂O precursor, and CuS flower was synthesized through a simple solvothermal approach. Their electrochemical performances were investigated towards H₂O₂ and it was interesting to discover that Cu₇S₄ nanocrystal had the best electrochemical catalysis compared with CuS sphere and CuS flower. It can deduce that the special structure of Cu₇S₄ nanocrystal endowed it more exposed active points, higher surface area and higher Cu/S ratio. Therefore, Cu₇S₄ nanocrystal was firstly employed to prepare a nonenzymatic biosensor for H₂O₂. Satisfactory results were obtained. In addition, a label-free sensing platform for prostate specific antigen (PSA) was constructed based on electrochemical catalysis towards H₂O₂ of Cu₇S₄ nanocrystal. The label-free immunosenosr offered accurate PSA in the range of 0.001–15 ng/mL with the detection limit of 0.001 ng/mL. Besides, the immunosensor possessed good sensitivity, selectivity and stability and could detect PSA in real sample. More importantly, this work demonstrated that Cu₇S₄ nanocrystal hold great promising application in electrochemical sensors.

用Cu ₂ O前驱体制备了18面多面体Cu ₇ S ₄纳米晶和CuS球，并通过简单的溶剂热法合成了CuS花。研究了它们对H ₂ O _2的电化学性能，有趣的是发现Cu ₇ S ₄纳米晶体与CuS球和CuS花相比具有最佳的电化学催化作用。可以推断出，Cu ₇ S ₄纳米晶体的特殊结构赋予了它更多的暴露活性点，更高的表面积和更高的Cu / S比。因此，Cu ₇ S ₄纳米晶体首先被用来制备用于H ₂ O ₂的非酶生物传感器。获得满意的结果。另外，基于对Cu ₇ S ₄纳米晶体的H ₂ O ₂的电化学催化，构建了针对前列腺特异性抗原（PSA）的无标记传感平台。无标记的免疫传感器可在0.001–15 ng / mL范围内提供准确的PSA，检出限为0.001 ng / mL。此外，该免疫传感器具有良好的灵敏度，选择性和稳定性，可以检测真实样品中的PSA。更重要的是，这项工作证明了Cu ₇ S ₄ 纳米晶在电化学传感器中具有广阔的应用前景。