Abstract Poly(e-caprolactone) (PCL) has been blended with Chloramphenicol (CAM), a well-known bacteriostatic antibiotic, in order to obtain new biomaterials with antibacterial properties. The resulting samples have been thoroughly characterized regarding both their physicochemical behavior and antimicrobial efficacy by means of very diverse techniques. Hence, PCL/CAM blend miscibility has been analyzed by Differential Scanning Calorimetry (DSC) using the single glass transition temperature (Tg) criterion, intermediate between those corresponding to the two components in the blend. In turn, the interaction parameter has been obtained from the analysis of the melting point depression in both PCL-rich and CAM-rich blends. Fourier-Transform Infra-Red (FTIR) spectroscopy and X-Ray Diffraction (XRD) analysis have been used -in the pure components and in the blends- to analyze both the specific interactions and the crystallization behavior, respectively. The morphology of PCL/CAM blends obtained by spin-coating has been also studied by means of Atomic Force Microscopy (AFM). Finally, drug release kinetics of different PCL/CAM systems as well as their antibacterial efficacy against Escherichia Coli have been investigated, indicating that CAM can be released from the PCL/CAM blends in a controlled way while keeping intact the antibacterial efficiency.

中文翻译：

---

聚（ε-己内酯）/氯霉素混合物的混溶性、相互作用和抗菌活性

摘要 聚ε-己内酯（PCL）与著名的抑菌抗生素氯霉素（CAM）共混，以获得具有抗菌性能的新型生物材料。通过非常多样化的技术，已经对所得样品的理化行为和抗菌功效进行了彻底的表征。因此，PCL/CAM 混合物的混溶性已通过差示扫描量热法 (DSC) 使用单一玻璃化转变温度 (Tg) 标准进行分析，该标准介于与混合物中两种组分对应的温度之间。反过来，相互作用参数是从富含 PCL 和富含 CAM 的混合物的熔点下降分析中获得的。傅里叶变换红外 (FTIR) 光谱和 X 射线衍射 (XRD) 分析已用于 - 在纯组分和共混物中 - 分别用于分析特定相互作用和结晶行为。还通过原子力显微镜 (AFM) 研究了通过旋涂获得的 PCL/CAM 混合物的形态。最后，研究了不同 PCL/CAM 系统的药物释放动力学及其对大肠杆菌的抗菌功效，表明 CAM 可以受控方式从 PCL/CAM 混合物中释放，同时保持完整的抗菌效率。