Growing evidence has suggested that mindfulness-based interventions (MBIs) could have beneficial effects on the acute phase of depression and on the prevention of depressive relapse or recurrence. Despite growing clinical interest, the effects of MBIs on brain functioning in patients with MDD remain unclear. The aim of this systematic review was to assess the changes in brain functioning associated with MBIs in patients with MDD. A systematic search was conducted, and of the 56 articles found, 8 were eligible. MBIs have modulatory effects on several brain regions implicated in the pathophysiology of MDD, such as the prefrontal cortex, the basal ganglia, the anterior and posterior cingulate cortices, and the parietal cortex. These regions have been implicated in self-awareness, attention and emotion regulation. Some of these findings were consistent with the effects of MBIs observed in healthy subjects and patients with other psychiatric disorders, especially enhanced activity in the frontal and subcortical regions related to the improved somatosensory awareness. Further studies are needed to elucidate the mechanisms of MBIs in MDD.

越来越多的证据表明，基于正念的干预（MBI）可能对抑郁症的急性期和预防抑郁症复发或复发具有有益的作用。尽管临床兴趣日益增长，但尚不清楚MBI对MDD患者脑功能的影响。这项系统评价的目的是评估MDD患者与MBI相关的脑功能变化。进行了系统的搜索，在找到的56篇文章中，有8篇符合条件。MBI对涉及MDD病理生理的几个大脑区域具有调节作用，例如前额叶皮层，基底神经节，前扣带和后扣带皮层以及顶叶皮层。这些区域与自我意识，注意力和情绪调节有关。这些发现中的一些与在健康受试者和其他精神病患者中观察到的MBI的作用一致，尤其是与改善的体感意识有关的额叶和皮层下区域活动的增强。需要进一步的研究来阐明MDD中MBI的机制。