Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting pool of potential ligands since they have been refined under evolutionary pressure to interact with proteins or other biological targets.

This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed.

中文翻译：

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天然产物作为核受体和代谢传感器LXR，FXR和RXR的调节剂

核受体（NRs）代表了治疗代谢综合征相关疾病的诱人靶标。另外，天然产物是令人感兴趣的潜在配体库，因为它们已经在进化压力下进行了精制以与蛋白质或其他生物靶标相互作用。

这篇综述旨在简要总结有关肝X（LXR）和法尼醇X受体（FXR）的当前基础知识，这些受体与类视黄醇X受体（RXR）形成了允许的异二聚体。总结了基于天然产物的这些受体的配体，并讨论了LXR，FXR和RXR作为精密医学靶标的潜力。