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Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?
Trends in Microbiology ( IF 15.9 ) Pub Date : 2018-03-13 , DOI: 10.1016/j.tim.2018.02.009
James A. Tsatsaronis , Sandra Franch-Arroyo , Ulrike Resch , Emmanuelle Charpentier

Both extracellular RNAs and extracellular vesicles (EVs) have recently garnered attention as novel mediators of intercellular communication in eukaryotes and prokaryotes alike. EVs not only permit export of RNA, but also facilitate delivery and trans-kingdom exchange of these and other biomolecules, for instance between microbes and their hosts. In this Opinion article, we propose that EV-mediated export of RNA represents a universal mechanism for interkingdom and intrakingdom communication that is conserved among bacterial, archaeal, and eukaryotic microbes. We speculate how microbes might use EV RNA to influence target cell gene expression or manipulate host immune responses.



中文翻译:

细胞外囊泡RNA:微生物传播的通用介体?

作为真核生物和原核生物中细胞间通讯的新型介体,细胞外RNA和细胞外囊泡(EV)最近都受到关注。电动汽车不仅允许RNA的输出,而且还促进了这些微生物和其他生物分子的传递和跨王国交换,例如在微生物与其宿主之间。在这篇观点文章中,我们建议EV介导的RNA出口代表细菌,古细菌和真核微生物之间保守的相互间和相互间通讯的通用机制。我们推测微生物可能如何使用EV RNA来影响靶细胞基因表达或操纵宿主免疫反应。

更新日期:2018-03-13
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