Coenzyme Q₁₀ (CoQ₁₀) is a ubiquitous molecule present in all eukaryotic organisms whose principal role in the cell is related to its participation in the electron transport chain in the inner mitochondrial membrane. CoQ₁₀ plays a major role in the control of cell redox status, and both the amount and functionality of this molecule have been related to the regulation of reactive oxygen species generation. Numerous reports can be found discussing the implications of CoQ₁₀ supplementation in human studies and clinical trials related to aging. However, few reviews have made an updating through the translational point of view to integrate both basic and clinical aspects. The aim of this paper is to review our current knowledge from CoQ₁₀ implications at biochemical and physiological level, in order to unravel the molecular mechanisms involved in its application in clinical practice. Although the importance of CoQ₁₀ has been mainly attributed to its role as an agent for energy transduction in mitochondria, new functions for CoQ₁₀ have been described in the recent past years, including anti-inflammatory effects, gene expression regulation and lipid bilayer membranes stabilization, which explain its involvement in aging and age-related diseases such as cardiovascular diseases, renal failure and neurodegenerative diseases.

中文翻译：

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辅酶Q ₁₀：从长凳到诊所，应对衰老疾病，进行翻译回顾

辅酶Q ₁₀（CoQ ₁₀）是存在于所有真核生物中的普遍存在的分子，其在细胞中的主要作用与其在线粒体内膜中的电子传输链的参与有关。辅酶Q ₁₀在细胞氧化还原状态的控制中起着重要作用，并且该分子的数量和功能都与活性氧物种生成的调节有关。可以找到许多报告，讨论辅酶Q ₁₀补充剂在人体研究和与衰老相关的临床试验中的意义。但是，很少有评论通过翻译的观点对基础和临床方面进行整合。本文的目的是回顾来自CoQ的当前知识为了揭示其在临床实践中的应用所涉及的分子机制，在生化和生理学水平上具有_10个意义。尽管辅酶Q ₁₀的重要性主要归因于其作为线粒体能量转导剂的作用，但近年来已描述了辅酶Q _10的新功能，包括抗炎作用，基因表达调控和脂质双层膜稳定，这解释了它参与了衰老和与年龄有关的疾病，例如心血管疾病，肾衰竭和神经退行性疾病。