Spirocyclic pyrrolidines are structural motifs frequently found in a wide variety of natural products, pharmaceuticals and biologically significant compounds. In the past few years, catalytic asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides have shown to be one of the most straightforward methods for the stereoselective preparation of diverse biologically important spiropyrrolidine heterocycles in high yields with excellent enantioselectivities under mild reaction conditions. In this review, we will discuss the recent major developments in the catalytic enantioselective synthesis of chiral spiropyrrolidine derivatives since 2009.

中文翻译：

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通过偶氮甲亚胺的1，3-偶极环加成反应 催化合成螺吡咯烷

螺环吡咯烷是在多种天然产物，药物和生物学上重要的化合物中经常发现的结构基序。在过去的几年中，偶氮甲亚胺的不对称催化1,3-偶极环加成反应已被证明是在温和的反应条件下以高收率立体选择性地制备具有重要对映选择性的多种生物学重要螺吡咯烷杂环的最直接方法之一。在这篇综述中，我们将讨论自2009年以来手性螺吡咯烷衍生物催化对映体选择性合成的最新进展。