In the search for new therapeutic agents against neglected diseases, both aqueous and hydroethanolic extracts from Psidium guajava L. and P. brownianum Mart ex DC leaves were investigated regarding their antiparasitic effect and cytotoxic potential. The extracts were tested at three concentrations (250, 500 and 1000 μg/mL) against Trypanosoma cruzi epimastigote forms (Chagas, 1909), Leishmania braziliensis (Vianna, 1911) and L. infantum promastigotes forms (Nicolle, 1908), as well as against fibroblasts. P. guajava showed no activity against T. cruzi forms, while the hydroethanolic (PBHE), aqueous by decoction (PBAED) and aqueous by infusion (PBAEI) P. browninaum extracts were responsible, respectively, for inhibiting 100, 100 and 92.68% of T. cruzi epimastigote growth at the 1000 μg/mL concentration. The P. brownianum hydroethanolic extract (PBHE) at the highest concentration caused 58.46% death in L. braziliensis, thus demonstrating moderate activity, however when tested against L. infantum, the PBHE inhibited their growth by 37.16%, revealing its low activity. As for the cytotoxicity assays, the P. brownianum aqueous extract by decoction (PBAED) obtained the highest death percentage when compared to the others, causing 90.85% fibroblast mortality at the 1000 μg/mL concentration.

在寻找被忽视的疾病的新治疗药物，从水性和hydroethanolic提取番石榴L.和P. brownianum沃尔玛EX DC叶子就其抗寄生虫效果和细胞毒性潜力进行了调查。测试了三种浓度（250、500和1000μg/ mL）提取物的抗克鲁斯锥虫（Chagas，1909），巴西利什曼原虫（Vianna，1911）和婴儿乳杆菌（L. infantum promastigotes ）（Nicolle，1908）的浓度。反对成纤维细胞。P. guajava对T. cruzi形式没有活性，而氢乙醇（PBHE），水煎汤（PBAED）和水浸输液（PBAEI）P. browninaum提取物分别负责，用于抑制100,100和92.68％锥虫在1000μg/ mL的浓度epimastigote增长。的P. brownianum在最高浓度hydroethanolic提取物（PBHE）引起58.46％死亡L. braziliensis，因此证明中度活性，然而，当对所测试的婴儿利什曼原虫，所述PBHE由37.16％的抑制它们的生长，揭示其低活性。作为用于细胞毒性测定，所述P. brownianum比别人时，在1000μg/ mL的浓度导致90.85％的成纤维细胞的死亡率含水提取物通过汤（PBAED）中获得的最高百分比死亡。