Over the recent decade tremendous interest has been developed on the synthetic modification of natural as well as non‐proteinogenic amino acids and non‐natural linkages due to their immensely important applications in proteomics, diagnosis, and drug delivery etc. They are synthetically important also. For example, due to the high natural abundance of enantiopure amino acids, they and their derivatives are regularly employed in the development of several interesting synthetic methods, total syntheses of biologically related structures as well as in ligand elaboration. Thus, the synthetic field possesses a direct impact on several basic and applied sciences. But up to date only limited numbers of reviews are available which either appeared almost half a decade earlier or covered very specific areas of this highly expanding topic. Many achievements have already been realized in this field in the meantime which urgently need to be documented. Therefore, to meet the need this review is intended to cover the emerging versatile synthetic methods on the modification of amino acids and related structures over the recent decade with the relevant details of their respective prospects and problems in the best possible systematic and concise manner. Wherever needed relevant mechanistic details are also described.

中文翻译：

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通过C–H功能化和脱羧功能化策略对氨基酸进行修饰的最新进展

近十年来，由于天然，非蛋白质氨基酸和非天然键合在蛋白质组学，诊断和药物输送等方面的重要应用，人们对它们的合成修饰产生了极大的兴趣。它们在合成上也很重要。例如，由于对映纯氨基酸的天然丰富性高，它们和它们的衍生物经常用于开发几种有趣的合成方法，生物相关结构的总合成以及配体的制备中。因此，合成领域对几种基础科学和应用科学具有直接影响。但是到目前为止，只有有限数量的评论可用，这些评论要么出现在将近五年前，要么涵盖了这个高度扩展的主题的非常具体的领域。同时，在该领域已经取得了许多成就，迫切需要记录在案。因此，为了满足需要，本综述旨在以尽可能系统和简洁的方式，涵盖最近十年来对氨基酸和相关结构进行修饰的新兴通用合成方法，并详细介绍其各自的前景和问题。还在需要的地方描述了相关的机械细节。为了满足需要，本综述旨在以尽可能系统和简洁的方式，涵盖最近十年来对氨基酸和相关结构进行修饰的新兴通用合成方法，并详细介绍其各自的前景和问题。还在需要的地方描述了相关的机械细节。为了满足需要，本综述旨在以尽可能系统和简洁的方式，涵盖最近十年来对氨基酸和相关结构进行修饰的新兴通用合成方法，并详细介绍其各自的前景和问题。还在需要的地方描述了相关的机械细节。