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Polyamidoamine Dendrimers as Crosslinkers for Efficient Electron Transfer between Redox Probes onto Magnetic Nanoparticles
ChemistrySelect ( IF 2.1 ) Pub Date : 2018-03-13 , DOI: 10.1002/slct.201703135
Feixiong Chen 1 , Naoufel Haddour 2 , Marie Frenea-Robin 3 , Yann Chevolot 1 , Virginie Monnier 1
Affiliation  

The efficient conjugation of ferrocenecarboxylic acid (Fc), a usual electroactive probe, onto COOH‐modified magnetic nanoparticles (NPs) is reported. Amine crosslinkers were used to couple COOH groups from NPs and from Fc. The coupling efficiencies using different generations of polyamidoamine (PAMAM) dendrimer and ethylenediamine (EDA) were compared through zeta potential measurements, square‐wave voltammetry (SWV) and NH2 titration. Highest PAMAM generations led to NH2‐modified NPs with increased zeta potential and NH2 density compared to lowest ones. Moreover, no aggregation was observed after crosslinker grafting. SWV was applied to characterize Fc‐modified NPs. PAMAM generations 0–3 improved the electrochemical signal in comparison to EDA. However, increasing PAMAM generations led to NPs aggregation. Quantitative results supported the fact that PAMAM generation 0 was the best compromise for large electrochemical signal without NPs aggregation.

中文翻译:

聚酰胺胺树枝状聚合物作为交联剂,可有效地将氧化还原探针之间的电子转移到磁性纳米粒子上

据报道,二茂铁羧酸(Fc)(一种常见的电活性探针)可以有效地与COOH修饰的磁性纳米颗粒(NPs)结合。胺交联剂用于偶联来自NP和Fc的COOH基团。通过Zeta电位测量,方波伏安法(SWV)和NH 2滴定比较了使用不同代的聚酰胺酰胺(PAMAM)树枝状聚合物和乙二胺(EDA)的偶联效率。最高的PAMAM世代导致ze 2电位和NH 2增加的NH 2修饰的NP与最低的密度相比。此外,交联剂接枝后未观察到聚集。SWV用于表征Fc修饰的NP。与EDA相比,PAMAM的第0-3代改善了电化学信号。但是,增加的PAMAM世代导致了NP的聚集。定量结果支持以下事实:对于没有NP聚集的大型电化学信号,PAMAM第0代是最佳折衷方案。
更新日期:2018-03-13
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