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Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?
Biomaterials ( IF 14.0 ) Pub Date : 2018-03-12 , DOI: 10.1016/j.biomaterials.2018.03.017
O. Guillaume , R. Pérez-Tanoira , R. Fortelny , H. Redl , T.F. Moriarty , R.G. Richards , D. Eglin , A. Petter Puchner

The incidence of mesh-related infection after abdominal wall hernia repair is low, generally between 1 to 4 %; however, worldwide, this corresponds to tens of thousands of difficult cases to treat annually. Adopting best practices in prevention is one of the keys to reduce the incidence of mesh-related infection. Once the infection is established, however, only a limited number of options are available that provides an efficient and successful treatment outcome. Over the past few years, there has been a tremendous amount of research dedicated to the functionalization of prosthetic meshes with antimicrobial properties, with some receiving regulatory approval and are currently available for clinical use. In this context, it is important to review the clinical importance of mesh infection, its risk factors, prophylaxis and pathogenicity. In addition, we give an overview of the main functionalization approaches that have been applied on meshes to confer anti-bacterial protection, the respective benefits and limitations, and finally some relevant future directions.



中文翻译:

与腹壁疝的网状修复相关的感染:抗菌生物材料是否是人们渴望的解决方案?

腹壁疝修补术后网状相关感染的发生率很低,通常在1-4%之间。然而,在世界范围内,这相当于每年要处理成千上万的困难病例。采取最佳预防措施是减少网状相关感染发生率的关键之一。然而,一旦感染被建立,只有有限数量的选择可用于提供有效和成功的治疗结果。在过去的几年中,已经进行了大量的研究,致力于具有抗菌特性的假体网片的功能化,其中一些已获得监管部门的批准,目前可用于临床。在这种情况下,重要的是回顾网状感染的临床重要性,其危险因素,预防和致病性。此外,

更新日期:2018-03-13
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