I read with great interest the article by Dr Aubdool and colleagues¹ dealing with the effects of a novel potent and long-lasting acetylated α-calcitonin gene-related peptide (α-CGRP) analogue on cardiovascular damages in 2 distinct murine models of hypertension and heart failure in vivo. The results of their study demonstrated that the angiotensin II–induced hypertension was attenuated by cotreatment of α-CGRP analogue. The α-CGRP analogue protected against vascular, renal, and cardiac dysfunction, characterized by reduced hypertrophy and biomarkers of fibrosis, remodeling, inflammation, and oxidative stress. In addition, the authors …

中文翻译：

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Tsuda关于文章的信，“一种新型的与降钙素基因相关的肽类似物可预防实验性高血压，心脏肥大和心力衰竭中的末端器官损伤”

我非常感兴趣地阅读了Aubdool博士及其同事¹的文章，其中涉及新型有效且持久的乙酰化α降钙素基因相关肽（α-CGRP）类似物在2种不同的高血压和高脂血症小鼠模型中对心血管损害的影响体内心力衰竭。他们的研究结果表明，α-CGRP类似物的共同治疗可减轻血管紧张素II引起的高血压。α-CGRP类似物可预防血管，肾脏和心脏功能障碍，其特征在于肥大和纤维化，重塑，炎症和氧化应激的生物标记物减少。此外，作者…