We thank Drs Jin-shan and Xue-bin for their comments concerning our article.¹ We agree that the results were highly positive for protecting against cardiovascular dysfunction in the 2 murine models.¹ Here are our answers to their questions:

We do not yet know the mechanisms involved in the protective effects of α–calcitonin gene-related peptide (CGRP) from an in vivo perspective. There is evidence from in vitro studies that CGRP has blood pressure–independent effects, as discussed in the article. However, this is the first time we have been able to use a CGRP agonist that is long-lasting in vivo.

We are asked about the mechanisms of α-CGRP involved in the ejection fraction–improving effects. This is partly answered in (1). We used …

感谢金山博士和薛斌对本文的评论。¹我们同意，在2种小鼠模型中，该结果对于预防心血管功能异常具有高度积极意义。¹这是我们对他们的问题的答案：

从体内角度来看，我们还不知道α-降钙素基因相关肽（CGRP）的保护作用所涉及的机制。如本文所述，体外研究表明CGRP具有血压独立作用。但是，这是我们第一次能够使用在体内持久存在的CGRP激动剂。

我们被问到α-CGRP参与射血分数改善作用的机制。这在（1）中得到了部分回答。我们用了 …