Metastases arising from tumors have the proclivity to colonize specific organs, suggesting that they must rewire their biology to meet the demands of the organ colonized, thus altering their primary properties. Each metastatic site presents distinct metabolic challenges to a colonizing cancer cell, ranging from fuel and oxygen availability to oxidative stress. Here, we discuss the organ-specific metabolic adaptations that cancer cells must undergo, which provide the ability to overcome the unique barriers to colonization in foreign tissues and establish the metastatic tissue tropism phenotype.

中文翻译：

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独特的代谢适应性决定了远端器官特异性转移定植。

肿瘤引起的转移倾向于在特定器官中定殖，这表明它们必须重新排列生物学才能满足被定殖器官的需求，从而改变其主要特性。每个转移部位都对定居的癌细胞提出了独特的代谢挑战，范围从燃料和氧气的利用到氧化应激。在这里，我们讨论了癌细胞必须经历的器官特异性代谢适应，这提供了克服异物组织定植的独特障碍并建立转移性组织嗜性表型的能力。