The suprachoroidal space (SCS) is a potential space between the sclera and choroid that traverses the circumference of the posterior segment of the eye. The SCS is an attractive site for drug delivery because it targets the choroid, retinal pigment epithelium, and retina with high bioavailability, while maintaining low levels elsewhere in the eye. Indeed, phase III clinical trials are investigating the safety and efficacy of SCS drug delivery. Here, we review the anatomy and physiology of the SCS; methods to access the SCS; kinetics of SCS drug delivery; strategies to target within the SCS; current and potential clinical indications; and the safety and efficacy of this approach in preclinical animal studies and clinical trials.

脉络膜上腔（SCS）是巩膜和脉络膜之间的一个潜在空间，横穿眼后段的周围。SCS是药物输送的一个吸引人的场所，因为它以高生物利用度为脉络膜，视网膜色素上皮和视网膜，同时在眼睛其他部位保持较低的水平。实际上，III期临床试验正在研究SCS药物递送的安全性和有效性。在这里，我们回顾了SCS的解剖学和生理学；访问SCS的方法；SCS药物递送动力学；在SCS中定位的策略；当前和潜在的临床适应症；以及这种方法在临床前动物研究和临床试验中的安全性和有效性。