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Metal–Organic Framework as a Simple and General Inert Nanocarrier for Photosensitizers to Implement Activatable Photodynamic Therapy
Advanced Functional Materials ( IF 19.0 ) Pub Date : 2018-03-12 , DOI: 10.1002/adfm.201707519 Fang Hu 1 , Duo Mao 1 , Kenry 1 , Yuxiang Wang 1 , Wenbo Wu 1 , Dan Zhao 1 , Deling Kong 2 , Bin Liu 1
Advanced Functional Materials ( IF 19.0 ) Pub Date : 2018-03-12 , DOI: 10.1002/adfm.201707519 Fang Hu 1 , Duo Mao 1 , Kenry 1 , Yuxiang Wang 1 , Wenbo Wu 1 , Dan Zhao 1 , Deling Kong 2 , Bin Liu 1
Affiliation
There has been a surging interest in the synthesis of activatable photosensitizers (PSs) as they can be selectively activated with minimum nonspecific phototoxic damages for photodynamic therapy (PDT). Conventional strategies to realize activatable PSs are only applicable to a limited number of molecules. Herein, a simple and general strategy to yield activatable PSs by coupling MIL‐100 (Fe) (MIL: Materials Institute Lavoisier) with different kinds of PSs is presented. Specifically, when PSs are encapsulated into MIL‐100 (Fe), the photosensitization capability is suppressed due to their isolation from O2. After the reaction between iron(III) in MIL‐100 (Fe) and H2O2 occurs, the framework of MIL‐100 (Fe) collapses and the encapsulated PSs regain contact with O2, leading to activation of photosensitization. In addition, the decomposition of H2O2 can generate O2 to relieve tumor hypoxia and enhance PDT effect. As O2 is an indispensable factor for PDT, the activation strategy should be generally applicable to different PSs for activatable PDT.
中文翻译:
金属有机框架作为用于光敏剂的简单和通用的惰性纳米载体,以实施可活化的光动力疗法
人们对可激活的光敏剂(PSs)的合成产生了极大的兴趣,因为它们可以选择性地激活,而光动力疗法(PDT)的非特异性光毒性损害最小。实现可激活PS的常规策略仅适用于有限数量的分子。本文提出了一种简单通用的策略,通过将MIL-100(Fe)(MIL:材料研究所Lavoisier)与不同种类的PS偶联来生产可活化PS。具体而言,将PS封装到MIL-100(Fe)中时,由于将它们与O 2隔离,因此光敏能力受到抑制。在MIL-100(Fe)中的铁(III)与H 2 O 2之间发生反应后,MIL-100(Fe)的骨架崩溃,被封装的PS重新与O接触2,导致光敏作用的激活。另外,H 2 O 2的分解可产生O 2,以减轻肿瘤的缺氧并增强PDT的作用。由于O 2是PDT不可或缺的因素,因此激活策略通常应适用于可激活PDT的不同PS。
更新日期:2018-03-12
中文翻译:
金属有机框架作为用于光敏剂的简单和通用的惰性纳米载体,以实施可活化的光动力疗法
人们对可激活的光敏剂(PSs)的合成产生了极大的兴趣,因为它们可以选择性地激活,而光动力疗法(PDT)的非特异性光毒性损害最小。实现可激活PS的常规策略仅适用于有限数量的分子。本文提出了一种简单通用的策略,通过将MIL-100(Fe)(MIL:材料研究所Lavoisier)与不同种类的PS偶联来生产可活化PS。具体而言,将PS封装到MIL-100(Fe)中时,由于将它们与O 2隔离,因此光敏能力受到抑制。在MIL-100(Fe)中的铁(III)与H 2 O 2之间发生反应后,MIL-100(Fe)的骨架崩溃,被封装的PS重新与O接触2,导致光敏作用的激活。另外,H 2 O 2的分解可产生O 2,以减轻肿瘤的缺氧并增强PDT的作用。由于O 2是PDT不可或缺的因素,因此激活策略通常应适用于可激活PDT的不同PS。