Chemical analysis of a fermentation of the Australian termite nest-derived fungus Trichoderma virens CMB-TN16 yielded five new acyclic nonapeptides, trichodermides A–E (1–5). Amino acid residues, configurations, and sequences were determined by a combination of spectroscopic (NMR and MS-MS) and chemical (C₃ Marfey’s) methods. The trichodermides adhere to the sequence homology pattern common to Trichoderma 11 amino acid residue peptaibols; however, unlike other peptaibols the trichodermides do not exhibit antibacterial or antifungal activity and exhibit low to no cytotoxicity against mammalian cells. This variability in biological activity highlights the importance of knowing both planar structures and absolute configurations when interpreting structure–activity relationships.

中文翻译：

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Trichodermides A–E：从澳大利亚白蚁巢衍生真菌分离的新肽类木霉CMB-TN16

澳大利亚白蚁巢衍生真菌的发酵的化学分析绿木霉CMB-TN16产生五个新的无环的九肽，trichodermides A-E（1 - 5）。氨基酸残基，构型和序列通过光谱法（NMR和MS-MS）和化学法（C ₃ Marfey法）的结合来确定。曲霉毒素遵守木霉菌常见的序列同源性模式11个氨基酸残基肽醇；然而，与其他肽类药物不同，曲霉酰胺不具有抗菌或抗真菌活性，并且对哺乳动物细胞的毒性低至无。生物活性的这种可变性突出了在解释结构-活性关系时了解平面结构和绝对构型的重要性。