Dual-energy CT (DECT) and MRI are advanced imaging methods used to visualise gout pathology. DECT can identify monosodium urate (MSU) crystals in people with gout,1 ,2 and also has conventional CT properties, allowing assessment of tophus and bone pathology.3 ,4 MRI is used to assess inflammation, bone erosion and cartilage damage in gout.5–7 This study aimed to compare DECT and MRI with corresponding anatomical pathology in the assessment of gout. Cadaveric joint specimens were obtained from two donors; a donor aged 82 years with crystal-proven tophaceous gout and a control donor aged 89 years without gout (12 joints from each). All joints were scanned by DECT (SOMATOM Definition Flash, Siemens Medical, Erlangen, Germany) and MRI (3T MAGNETOM Skyra, Siemens Medical), and then processed for histology, including digital photography of sectioned digits (sagittal plane) for macroscopic analysis, and preparation of histology slides from each individual joint for microscopic analysis. Slides were stained with H&E or 1% toluidine blue. Collection and use of cadaveric tissue was in accordance with the New Zealand Human Tissue Act 2008. All images and histology data were systematically assessed for gout pathology by experienced readers who were blinded to diagnosis and each other's scores. …

中文翻译：

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痛风的高级影像评估：双能 CT 和 MRI 与解剖病理的比较

双能 CT (DECT) 和 MRI 是用于可视化痛风病理的先进成像方法。DECT 可以识别痛风患者的单钠尿酸盐 (MSU) 晶体，1 ,2 并且还具有常规 CT 特性，可以评估痛风石和骨骼病理。3 ,4 MRI 用于评估痛风中的炎症、骨侵蚀和软骨损伤。 5-7 本研究旨在将 DECT 和 MRI 与相应的解剖病理学在痛风评估中进行比较。尸体关节标本来自两名捐赠者；一名 82 岁的捐赠者患有经晶体证实的痛风石，一名 89 岁的对照捐赠者没有痛风（每人 12 个关节）。所有关节均通过 DECT（SOMATOM Definition Flash，Siemens Medical，Erlangen，Germany）和 MRI（3T MAGNETOM Skyra，Siemens Medical）进行扫描，然后进行组织学处理，包括用于宏观分析的切片数字（矢状面）的数字摄影，以及从每个单独的关节制备组织学载玻片用于微观分析。载玻片用 H&E 或 1% 甲苯胺蓝染色。尸体组织的收集和使用符合 2008 年新西兰人体组织法。所有图像和组织学数据都由经验丰富的读者系统地评估痛风病理学，他们对诊断和彼此的分数不知情。… 所有图像和组织学数据都由经验丰富的读者系统地评估痛风病理，他们对诊断和彼此的分数不知情。… 所有图像和组织学数据都由经验丰富的读者系统地评估痛风病理，他们对诊断和彼此的分数不知情。…