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Carboxymethyl guar gum synthesis in homogeneous phase and macroporous 3D scaffolds design for tissue engineering
Carbohydrate Polymers ( IF 11.2 ) Pub Date : 2018-03-11 , DOI: 10.1016/j.carbpol.2018.03.007
Sonia Kundu , Aatrayee Das , Aalok Basu , Debjani Ghosh , Pallab Datta , Arup Mukherjee

Guar gum (GG) is a galactomannan obtained directly from the Cyamopsis tetragonoloba seeds pericarb. The biopolymer hydrates hugely in three chain associated coil formations. Chaotropic Hofmeister ion like lithium interacts at the hydrogen bonding sites and render GG homogenization in polar solvents like dimethyl sulfoxide. This phenomenon was used for the first time for galactomannan derivatisations in homogeneous phase. Higher degree of substitution (DS) that was hereto unattainable in GG was achieved due to Hofmeister ion assisted assembly deformations. Furthermore, carboxymethyl guar gum (CMGG, DS = 1.10) blends well in poly-vinyl alcohol (PVA) at 2:1 mass ratio and enabled hydrophilic porous scaffold design for cell propagation. CMGG-PVA scaffolds porosity was 70–90% and the tensile strength was 6.32 MPa. CMGG-PVA scaffolds were useful as cell factories and in tissue engineering. New generation guar gum derivative scaffolds were non cytotoxic and permitted cell propagation in growth medium.



中文翻译:

均相和大孔3D支架的羧甲基瓜尔胶合成设计用于组织工程

瓜尔胶(GG)是一种半乳甘露聚糖,直接从C. yamopsis tetragonoloba中获得种子无糖。生物聚合物在三个与链相关的螺旋结构中大量水合。像锂一样的离液型霍夫迈斯特离子在氢键处相互作用,并在极性溶剂(如二甲基亚砜)中使GG均质化。该现象首次用于均相中的半乳甘露聚糖衍生化。由于霍夫迈斯特离子辅助的组装变形,在GG中无法达到更高的取代度(DS)。此外,羧甲基瓜尔胶(CMGG,DS = 1.10)在聚乙烯醇(PVA)中以2:1的质量比充分混合,并为细胞繁殖提供了亲水性多孔支架设计。CMGG-PVA支架的孔隙率为70-90%,抗拉强度为6.32 MPa。CMGG-PVA支架可用作细胞工厂和组织工程。

更新日期:2018-03-12
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