Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), the two most common primary liver cancers, represent the second most common cancer-related cause of death worldwide, with most cases being diagnosed at an advanced stage. Recent genome-wide studies have helped to elucidate the molecular pathogenesis and genetic heterogeneity of liver cancers. This review of the genetic landscape of HCC and iCCA discusses the most recent findings from genomic profiling and the current understanding of the pathways involved in the initiation and progression of liver cancer. We highlight recent insights gained from metabolic profiling of HCC and iCCA. This knowledge will be key to developing clinically useful diagnostic/prognostic profiles, building targeted molecular and immunologic therapies, and ultimately curing these complex and heterogeneous diseases.

两种最常见的原发性肝癌肝细胞癌（HCC）和肝内胆管癌（iCCA）代表了全球第二大最常见的与癌症相关的死亡原因，大多数病例都被诊断为晚期。最近的全基因组研究有助于阐明肝癌的分子发病机制和遗传异质性。这篇关于HCC和iCCA的遗传学概况的综述讨论了来自基因组图谱的最新发现以及对肝癌的发生和发展所涉及的途径的当前理解。我们重点介绍了从HCC和iCCA的代谢谱分析中获得的最新见解。这些知识将是开发临床上有用的诊断/预后资料，建立有针对性的分子和免疫疗法的关键，