当前位置: X-MOL 学术Ann. Rheum. Dis. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cell function in disease: there are more than two parties at play
Annals of the Rheumatic Diseases ( IF 27.4 ) Pub Date : 2018-03-09 , DOI: 10.1136/annrheumdis-2018-213121
Jacques Behmoaras , Enrico Petretto

In the quest for identification of genes for complex disorders, the functional annotation of disease-risk variants in the relevant cell type remains a challenge. Lescoat and colleagues1 pose the question ‘ what is a scleroderma macrophage? ’ and in view of current literature (including the study by Moreno-Moral et al 2), argued how the heterogeneous range of activated macrophages can vary between target organs of interest and possibly across different fibrotic diseases. While we share Lescoat’s point of view on the underlying complexity of functional cells in disease, it remains open to debate whether GM-CSF or M-CSF-mediated differentiation conditions of peripheral blood monocytes are sufficient to fully capture the characteristics of these cells in their disease context. As stated by Lescoat et …

中文翻译:

疾病中的细胞功能:有两个以上在起作用

在寻找复杂疾病基因的过程中,相关细胞类型中疾病风险变异的功能注释仍然是一个挑战。Lescoat 和他的同事提出了一个问题“什么是硬皮病巨噬细胞?' 并鉴于当前的文献(包括 Moreno-Moral 等人的研究 2),争论了活化巨噬细胞的异质范围如何在感兴趣的靶器官之间以及可能在不同的纤维化疾病之间发生变化。虽然我们同意 Lescoat 对疾病中功能细胞的潜在复杂性的观点,但 GM-CSF 或 M-CSF 介导的外周血单核细胞分化条件是否足以完全捕捉这些细胞的特征仍然存在争议。疾病背景。正如 Lescoat 等人所说……
更新日期:2018-03-09
down
wechat
bug