The treatment of melanoma requires complete removal of tumor cells and simultaneous tissue regeneration of tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy of skin cancers and regeneration of skin tissue. CSO HMSs were synthesized with interior hollow and external nanoneedle microstructure, showing excellent drug-loading capacity and photothermal effects. With incorporation of drug-loaded CSO HMSs into the electrospun scaffolds, the composite scaffolds exhibited excellent photothermal effects and controlled NIR-triggered drug release, leading to distinctly synergistic chemo-photothermal therapy of skin cancer both in vitro and in vivo. Furthermore, such CSO HMSs-incorporated scaffolds could promote proliferation and attachment of normal skin cells and accelerate skin tissue healing in tumor-bearing and diabetic mice. Taken together, CSO HMSs-incorporated scaffolds may be used for complete eradication of the remaining tumor cells after surgery and simultaneous tissue healing, which offers an effective strategy for therapy and regeneration of tumor-initiated tissue defects.

中文翻译：

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含铜硅酸盐空心微球的支架用于化学光热疗法治疗黑素瘤和组织愈合

黑色素瘤的治疗需要彻底清除肿瘤细胞，并同时组织肿瘤引发的皮肤缺损的组织再生。本文中，掺有硅酸铜空心微球（CSO HMS）的生物活性支架被设计用于皮肤癌的化学光热疗法和皮肤组织的再生。合成了具有内部空心和外部纳米针微观结构的CSO HMS，显示出优异的载药量和光热效应。通过将载有药物的CSO HMS掺入电纺支架中，复合支架表现出出色的光热效应并控制NIR触发的药物释放，从而在体内和体外对皮肤癌进行了明显的协同化学光热疗法。。此外，这种掺有CSO HMS的支架可以促进正常皮肤细胞的增殖和附着，并促进荷瘤和糖尿病小鼠的皮肤组织愈合。综上所述，结合CSO HMS的支架可用于在手术和同时组织愈合之后彻底根除剩余的肿瘤细胞，这为治疗和再生肿瘤引发的组织缺损提供了有效的策略。