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Variation of mechanical properties and oxidation with radiation dose and source in highly crosslinked remelted UHMWPE
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.9 ) Pub Date : 2018-03-09 , DOI: 10.1016/j.jmbbm.2018.03.005
Mitchell Fung , John G. Bowsher , Douglas W. Van Citters

Ultra-high molecular weight polyethylene (UHMWPE) is the current gold standard for bearing materials used in total joint arthroplasty. High-dose radiation is commonly used to crosslink UHMWPE, thereby improving its wear resistance. A subsequent remelting step eliminates trapped residual free radicals to promote oxidative stability on the shelf, and to prevent material degradation over the long term. Assessment of clinically retrieved, highly crosslinked UHMWPE devices shows signs of unanticipated oxidation occurring in vivo, despite the absence of free radicals prior to implantation. These findings warrant further investigation into possible factors impacting this phenomenon along with its clinical implications. The overall objective of this work is to quantify the influence of irradiation dose and source on UHMWPE's oxidative stability, along with the effects of oxidation on the ultimate mechanical properties, including strength, ductility, and toughness. The results showed a strong positive correlation between maximum oxidation and initial transvinylene content. Critical oxidation levels in the context of mechanical property loss were determined for e-beam and gamma treatments at various radiation doses. Further, it was shown that critical oxidation was more dependent on radiation dose and less dependent on source. If in vivo oxidation persists in these devices, this can potentially lead to mechanical failure (e.g. fatigue damage) as observed in terminally gamma-sterilized devices.



中文翻译:

高度交联的重熔超高分子量聚乙烯的机械性能和氧化随辐射剂量和辐射源的变化

超高分子量聚乙烯(UHMWPE)是目前用于全关节置换术的轴承材料的金标准。大剂量辐射通常用于交联UHMWPE,从而提高其耐磨性。随后的重熔步骤消除了残留的自由基,从而提高了货架上的氧化稳定性,并防止了材料的长期降解。对临床回收的高度交联的UHMWPE装置的评估显示,尽管在植入前没有自由基,但体内发生了意外氧化的迹象。这些发现需要进一步研究影响这一现象的可能因素及其临床意义。这项工作的总体目标是量化辐照剂量和来源对UHMWPE氧化稳定性的影响,以及氧化对最终机械性能(包括强度,延展性和韧性)的影响。结果显示最大氧化与初始反乙烯基含量之间有很强的正相关性。在各种辐射剂量下,对于电子束和伽马射线处理,在机械性能损失的情况下确定了临界氧化水平。此外,已表明临界氧化更多地依赖于辐射剂量而更少地依赖于放射源。如果这些设备中的体内氧化持续存在,则可能会导致机械故障(例如,疲劳损坏),如在最终的伽马灭菌设备中所观察到的那样。结果显示最大氧化与初始反乙烯基含量之间有很强的正相关性。在各种辐射剂量下,对于电子束和伽马射线处理,在机械性能损失的情况下确定了临界氧化水平。此外,已表明临界氧化更多地依赖于辐射剂量而更少地依赖于放射源。如果这些设备中的体内氧化持续存在,则可能会导致机械故障(例如,疲劳损坏),如在最终的伽马灭菌设备中所观察到的那样。结果显示最大氧化与初始反乙烯基含量之间有很强的正相关性。在各种辐射剂量下,对于电子束和伽马射线处理,在机械性能损失的情况下确定了临界氧化水平。此外,已表明临界氧化更多地依赖于辐射剂量而更少地依赖于放射源。如果这些设备中的体内氧化持续存在,则可能会导致机械故障(例如疲劳损坏),如在最终的伽马灭菌设备中所观察到的那样。

更新日期:2018-03-09
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