The [Cu(L)Cl₂]₂ and [Pt(L)Cl₂] complexes were prepared from the simple Schiff-base ligand (E)-phenyl-N-((pyridin-2-yl)methylene)methanamine (L) and respectively, CuCl₂ and cis-[PtCl₂(DMSO)₂]. DNA-interaction studies revealed that the copper complex most likely acts as a DNA cleaver whereas the platinum complex binds to the double helix. Remarkably, cell-viability experiments with HeLa, MCF7 and PC3 cells showed that [Cu(L)Cl₂]₂ is an efficient cytotoxic agent whereas [Pt(L)Cl₂] is not toxic, illustrating the crucial role played by the nature of the metal ion in the corresponding biological activity.

中文翻译：

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评估配位化合物的金属依赖性细胞毒性行为†

的[铜（L）氯₂ ] ₂和[PT（L）氯₂ ]是从简单的席夫碱配体（制备复合物ë） -苯基- ñ - （（吡啶-2-基）亚甲基）甲胺（大号）和分别的CuCl ₂和顺- [氯铂酸₂（DMSO）₂ ]。DNA相互作用研究表明，铜络合物最有可能充当DNA切割器，而铂络合物则结合在双螺旋上。值得注意的是，使用HeLa，MCF7和PC3细胞进行的细胞活力实验表明，[Cu（L）Cl ₂ ] ₂是有效的细胞毒剂，而[Pt（L）Cl ₂ ]无毒，说明了金属离子的性质在相应的生物活性中所起的关键作用。