Mechanochemistry has been established to be an environmentally-friendly way of conducting reactions in a solvent-free manner. The development of mechanochemical orthogonal reactions, in which multiple reagents are milled together, can be a powerful strategy to selectively yield the desired product. Such orthogonal syntheses are rare, especially those involving main group frameworks – based on bonds other than carbon – which are yet to be reported. Herein, we demonstrate the direct formation of air- and moisture-stable cyclophosph(V)azanes enabled by an orthogonal “one-step one-pot” mechanochemical reaction. In addition, detailed hydrolytic- and air-stability studies, conducted over one and 12 months, respectively, revealed high robustness of these compounds.

中文翻译：

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主要组化合物的正交性：通过机械化学直接一步合成空气和水分稳定的环磷氮烷†

机械化学已被确定为一种以无溶剂方式进行反应的环保方法。机械化学正交反应的发展（其中将多种试剂一起研磨）可能是选择性产生所需产物的有效策略。这种正交合成是罕见的，特别是那些涉及主要基团框架（基于除碳以外的键的基团）的正交合成，尚待报道。在这里，我们证明了通过正交的“一步式一锅法”机械化学反应能够直接形成空气和水分稳定的环磷（V）氮杂烷。此外，分别进行了1个月和12个月的详细水解稳定性和空气稳定性研究表明，这些化合物具有很高的耐用性。