Although the combination therapy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy has improved survival rates in selected patients with peritoneal metastasis (PM), therapeutic efficiency remains a challenge due to low targeting specificity, poor tissue penetration of chemotherapy drugs, and incomplete tumor clearance. To overcome these drawbacks, novel gold nanoshells conjugated with indocyanine green (I‐GSNs) for image‐guided photothermal adjunctive CRS (iPTA‐CRS) are synthesized. The as‐prepared nanoparticles effectively accumulate both in subcutaneously transplanted and PM models. I‐GSN‐mediated near‐infrared imaging provides sufficient optical contrast for preoperative guidance and intraoperative resection with the accurate detection of visible/microtumor lesions (<3 mm). The strategy is significantly more effective for removing subcutaneously transplanted tumors, inhibiting PM nodules of the gastric tumor, and enhancing the survival rate (≈33%) than other treatments (0%) in the 60 d observation period. This novel iPTA‐CRS may benefit future clinical translations for gastric cancer patients with PM.

中文翻译：

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光热辅助细胞还原术治疗胃癌腹膜转移

尽管减细胞手术（CRS）和腹膜内高温化疗的联合治疗可提高部分腹膜转移（PM）患者的生存率，但由于靶向特异性低，化疗药物的组织渗透性差以及肿瘤​​清除不完全，治疗效率仍然是一个挑战。为克服这些缺点，合成了新颖的金纳米壳，与吲哚菁绿（I-GSN）共轭，用于图像引导的光热辅助CRS（iPTA-CRS）。制备的纳米颗粒在皮下移植和PM模型中均有效积聚。I‐GSN介导的近红外成像可为术前指导和术中切除提供足够的光学对比，并能准确检测可见/微肿瘤病变（<3 mm）。在60天的观察期内，该策略与其他治疗（0％）相比，在清除皮下移植的肿瘤，抑制胃肿瘤的PM结节以及提高生存率（≈33％）方面更为有效。对于患有PM的胃癌患者，这种新颖的iPTA-CRS可能有益于将来的临床翻译。