In 1941 J. Heyrovský invented Oscillographic Polarography (OP) with controlled alternating current (a.c.). The method was developed during the World War and the first commercially available instruments for OP were produced in Czechoslovakia at the beginning of the 1950’s. Such instruments offered derivative and cyclic OP curves allowing simple analysis of various compounds and stimulated the publication of hundreds of papers. Thanks to OP, electrochemical analysis of DNA started already in 1958. According to the present nomenclature, OP can be denominated as a.c. chronopotentiometry. Surprisingly, authors who later described derivative and cyclic chronopotentiometry did not consider J. Heyrovský’s OP methodology in their work. Present electrochemical studies of biomacromolecules take advantage of modern instruments for constant current chronopotentiometric stripping, allowing DNA and protein structure-sensitive analysis. Recent progress in these studies is reviewed.

中文翻译：

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J. Heyrovský 的示波极谱法。当前生物大分子计时电位分析的根源

1941 年，J. Heyrovský 发明了具有受控交流电 (ac) 的示波极谱法 (OP)。该方法是在世界大战期间开发的，1950 年代初在捷克斯洛伐克生产了第一批商用 OP 仪器。这些仪器提供了导数和循环 OP 曲线，允许对各种化合物进行简单分析，并刺激了数百篇论文的发表。多亏了 OP，DNA 的电化学分析始于 1958 年。根据目前的命名法，OP 可以命名为 ac chronopotentiometry。令人惊讶的是，后来描述导数和循环计时电位法的作者在他们的工作中没有考虑 J. Heyrovský 的 OP 方法。目前的生物大分子电化学研究利用现代仪器进行恒流计时电位剥离，允许对 DNA 和蛋白质结构进行敏感分析。回顾了这些研究的最新进展。