To the Editor With interest we read the article by Hartwig et al.¹ The authors used 2-sample mendelian randomization² to investigate the role of C-reactive protein (CRP) in schizophrenia. Their main finding listed in the abstract and body is a pooled odds ratio estimate of 0.9 (random effects 95% CI, 0.84-0.97; P = .005) per 2-fold increment in CRP levels in their inverse variance–weighted random-effects model.

中文翻译：

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孟德尔随机化问题

致编辑我们感兴趣地阅读了Hartwig等的文章。¹作者使用2-样本孟德尔随机法²研究了C反应蛋白（CRP）在精神分裂症中的作用。他们的摘要和摘要中列出的主要发现是， 按反方差加权随机效应的CRP水平每增加2倍，汇总优势比估计为0.9（随机效应95％CI，0.84-0.97；P = .005）。模型。