Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. Whilst mechanochemical methods are solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivities and reduced reaction times will make it a technique of interest to synthetic chemists. Herein, we provide an overview of mechanochemistry reaction examples, with ‘direct’ comparators to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution.

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机械化学作为分子合成的新兴工具：它能提供什么？

随着新的机械化学反应被发现的频率不断增加，机械化学作为一种分子合成技术正变得越来越广泛。虽然机械化学方法是无溶剂的，因此可以提高可持续性指标，但反应结果、反应选择性和缩短反应时间之间的显着差异更有可能使其成为合成化学家感兴趣的技术。在此，我们提供了机械化学反应示例的概述，以及基于溶剂的反应的“直接”比较器，这些示例似乎共同表明，固态研磨可以缩短反应时间、产物选择性方面的不同反应结果以及在某些情况下不同的反应产物，包括在解决方案中无法访问的产品。