Synthesis ( IF 2.6 ) Pub Date : 2018-03-07 , DOI: 10.1055/s-0037-1609153 Tibor Soós , Dániel Horváth , Frigyes Domonyi , Roberta Palkó , Andrea Lomoschitz
Abstract
A general and versatile strategy has been developed for the functionalization of the carbocyclic core of the isoquinoline. This regioexhaustive approach employs electrophilic halogenation as a toolbox methodology and delivers highly decorated intermediates that can be further elaborated toward medicinally relevant building blocks or natural products.
A general and versatile strategy has been developed for the functionalization of the carbocyclic core of the isoquinoline. This regioexhaustive approach employs electrophilic halogenation as a toolbox methodology and delivers highly decorated intermediates that can be further elaborated toward medicinally relevant building blocks or natural products.
中文翻译:
异喹啉碳环核的区域穷竭功能化:氧杂卟啉核和玫瑰树碱的合成
摘要
已经开发了用于异喹啉碳环核心功能化的通用且通用的策略。这种区域穷举性方法采用亲电子卤化作为工具箱方法,并提供了装饰精美的中间体,可以将其进一步加工成与医学相关的构件或天然产物。
已经开发了用于异喹啉碳环核心功能化的通用且通用的策略。这种区域穷举性方法采用亲电子卤化作为工具箱方法,并提供了装饰精美的中间体,可以将其进一步加工成与医学相关的构件或天然产物。