The reaction of isoquinoline or quinoline with dialkyl acetylenedicarboxylates in the presence of alkyl 2-{3,5-dioxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene}acetates (generated in situ from acetylenedicarboxylates and 2-thiouracils) led to dialkyl 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,5H,11b′H-spiro{thiazolo[3,2-a]pyrimidine-3,2′-[1,3]oxazino[2,3-a]isoquinoline}-3′,4′-dicarboxylates or dialkyl 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,4a′H,5H-spiro{thiazolo[3,2-a]pyrimidine-3,2′-[1,3]oxazino[3,2-a]quinoline}-1′,2′-dicarboxylates in good yields. The structure of the target compounds was confirmed by X-ray diffraction study.

中文翻译：

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带有噻唑并嘧啶部分的螺环恶嗪基异喹啉和恶嗪基喹啉的合成

在烷基 2-{3,5-dioxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene} 的存在下异喹啉或喹啉与乙炔二羧酸二烷基酯的反应（由乙炔二羧酸和2-硫尿嘧啶）生成二烷基 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,5H,11b'H-spiro{thiazolo[3,2-a]pyrimidine-3,2'-[1 ,3]oxazino[2,3-a]isoquinoline}-3',4'-二羧酸盐或二烷基 2-(2-alkoxy-2-oxoethylidene)-5-oxo-2H,4a'H,5H-spiro{thiazolo [3,2-a]pyrimidine-3,2'-[1,3]oxazino[3,2-a]quinoline}-1',2'-dicarboxylates 收率良好。目标化合物的结构由X射线衍射研究证实。