当前位置: X-MOL 学术J. Chem. Eng. Data › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Volumetric Properties of Local Anesthetical Drug Lidocaine Hydrochloride in Aqueous and in Aqueous NaCl Solutions at Different Temperatures
Journal of Chemical & Engineering Data ( IF 2.6 ) Pub Date : 2018-03-07 00:00:00 , DOI: 10.1021/acs.jced.7b01059
Vasim R. Shaikh 1 , Vidya R. Salunke 1 , Karishma P. Behare 1 , Sayali E. Patil 1 , Amulrao U. Borse 1 , Kesharsingh J. Patil 1
Affiliation  

We report in this communication, the data on density measurements of binary aqueous solutions of lidocaine hydrochloride LC·HCl (0.00978 to 0.25412 mol·kg–1) as well as for ternary aqueous solutions containing a fixed concentration (0.09787 mol·kg–1 and 1.00764 mol·kg–1) of sodium chloride (NaCl) and varying the concentration (0.02046 to 0.24929 mol·kg–1) of LC·HCl at 288.15, 293.15, 298.15, 303.15, and 308.15 K. The density data are used to determine apparent molar volume (Vϕ) of the drug LC·HCl molecule at finite concentrations as well as apparent molar volume at infinitely dilute solutions (Vϕ0) in water and in aqueous NaCl solutions. The limiting apparent molar expansivity (Eϕ0) parameter of LC·HCl in binary and ternary aqueous NaCl solutions at 293.15, 298.15, and 303.15 K have also been computed. The transfer volumes ΔtrVϕ0, that is, volume change occurring when LC·HCl is transferred from water to aqueous NaCl solutions, are calculated. All these results are analyzed and discussed on the basis of solute–solvent, lidocaine cation–cation, and embrionic micelle forming interactions in aqueous salt solutions.

中文翻译:

不同温度下局部麻醉药盐酸利多卡因在NaCl水溶液和水溶液中的体积性质

我们在此通报中报告了关于利多卡因盐酸盐LC·HCl(0.00978至0.25412 mol·kg –1)的二元水溶液以及含固定浓度(0.09787 mol·kg –1和1.00764 mol·kg –1的氯化钠(NaCl),并更改288.15、293.15、298.15、303.15和308.15 K的LC·HCl浓度(0.02046至0.24929 mol·kg –1)。使用密度数据确定药物LC·HCl分子在有限浓度下的表观摩尔体积(V ϕ)以及在无限稀溶液中的表观摩尔体积(V ϕ 0)溶于水和氯化钠水溶液中。还计算了二元和三元NaCl水溶液在293.15、298.15和303.15 K下LC·HCl的极限表观摩尔膨胀系数(E ϕ 0)参数。该传送容积Δ TR V φ 0,即,当LC·HCl的从水中转移到含水NaCl溶液中发生体积变化,进行计算。所有这些结果都是在盐水溶液中溶质-溶剂,利多卡因阳离子-阳离子和胚胶团形成相互作用的基础上进行分析和讨论的。
更新日期:2018-03-07
down
wechat
bug