Nowadays, due to the advance of experimental techniques in glycomics, large collections of glycan profiles are regularly published. The rapid growth of available glycan data accentuates the lack of innovative tools for visualizing and exploring large amount of information. Scientists resort to using general-purpose spreadsheet applications to create ad hoc data visualization. Thus, results end up being encoded in publication images and text, while valuable curated data is stored in files as supplementary information. To tackle this problem, we have built an interactive pipeline composed with three tools: Glynsight, EpitopeXtractor and Glydin'. Glycan profile data can be imported in Glynsight, which generates a custom interactive glycan profile. Several profiles can be compared and glycan composition is integrated with structural data stored in databases. Glycan structures of interest can then be sent to EpitopeXtractor to perform a glycoepitope extraction. EpitopeXtractor results can be superimposed on the Glydin’ glycoepitope network. The network visualization allows fast detection of clusters of glycoepitopes and discovery of potential new targets. Each of these tools is standalone or can be used in conjunction with the others, depending on the data and the specific interest of the user. All the tools composing this pipeline are part of the Glycomics@ExPASy initiative and are available at https://www.expasy.org/glycomics.

中文翻译：

---

了解糖基：从糖组合物到糖表位的糖基化的互动观点

如今，由于糖组学实验技术的进步，定期出版大量的聚糖谱。可用聚糖数据的快速增长突显了缺乏用于可视化和探索大量信息的创新工具。科学家诉诸于使用通用电子表格应用程序来创建即席数据可视化。因此，结果最终被编码在出版物图像和文本中，而有价值的策划数据则作为补充信息存储在文件中。为了解决这个问题，我们建立了一个由三个工具组成的交互式管道：Glynsight，EpitopeXtractor和Glydin'。可以将Glycan配置文件数据导入Glynsight，后者会生成自定义的交互式聚糖配置文件。可以比较多个轮廓，并将聚糖成分与数据库中存储的结构数据集成在一起。然后可以将感兴趣的聚糖结构发送至EpitopeXtractor以进行糖表位提取。EpitopeXtractor结果可以叠加在Glydin的糖表位网络上。网络可视化可以快速检测糖表位簇，并发现潜在的新靶标。这些工具中的每一个都是独立的，也可以与其他工具结合使用，具体取决于数据和用户的特定兴趣。构成此管道的所有工具都是Glycomics @ ExPASy计划的一部分，可从https://www.expasy.org/glycomics获取。