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Vaccine adjuvants: Tailoring innate recognition to send the right message Immunity (IF 32.4) Pub Date : 2024-04-09 Ed C. Lavelle, Craig P. McEntee
Adjuvants play pivotal roles in vaccine development, enhancing immunization efficacy through prolonged retention and sustained release of antigen, lymph node targeting, and regulation of dendritic cell activation. Adjuvant-induced activation of innate immunity is achieved via diverse mechanisms: for example, adjuvants can serve as direct ligands for pathogen recognition receptors or as inducers of
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Control of adaptive immunity by pattern recognition receptors Immunity (IF 32.4) Pub Date : 2024-04-09 Shaina L. Carroll, Chandrashekhar Pasare, Gregory M. Barton
One of the most significant conceptual advances in immunology in recent history is the recognition that signals from the innate immune system are required for induction of adaptive immune responses. Two breakthroughs were critical in establishing this paradigm: the identification of dendritic cells (DCs) as the cellular link between innate and adaptive immunity and the discovery of pattern recognition
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Stressed out neutrophils drive metastasis Immunity (IF 32.4) Pub Date : 2024-04-09 Federico Lupo, Seth B. Coffelt
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The NLR family of innate immune and cell death sensors Immunity (IF 32.4) Pub Date : 2024-04-09 Balamurugan Sundaram, Rebecca E. Tweedell, Sivakumar Prasanth Kumar, Thirumala-Devi Kanneganti
Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition receptors that detect a wide variety of pathogenic and sterile triggers. Activation of specific NLRs initiates pro- or anti-inflammatory signaling cascades and the formation of inflammasomes—multi-protein complexes that
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Depression: Monocytes on my mind Immunity (IF 32.4) Pub Date : 2024-04-09 Gisela Paola Lazzarino, David Engblom
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Innate immune activation in neurodegenerative diseases Immunity (IF 32.4) Pub Date : 2024-04-09 Sergio Castro-Gomez, Michael T. Heneka
Activation of the innate immune system following pattern recognition receptor binding has emerged as one of the major pathogenic mechanisms in neurodegenerative disease. Experimental, epidemiological, pathological, and genetic evidence underscores the meaning of innate immune activation during the prodromal as well as clinical phases of several neurodegenerative disorders including Alzheimer’s disease
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Sensory neurons: An integrated component of innate immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Liwen Deng, Jacob E. Gillis, Isaac M. Chiu, Daniel H. Kaplan
The sensory nervous system possesses the ability to integrate exogenous threats and endogenous signals to mediate downstream effector functions. Sensory neurons have been shown to activate or suppress host defense and immunity against pathogens, depending on the tissue and disease state. Through this lens, pro- and anti-inflammatory neuroimmune effector functions can be interpreted as evolutionary
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The conceptual foundations of innate immunity: Taking stock 30 years later Immunity (IF 32.4) Pub Date : 2024-04-09 Thomas Pradeu, Bart P.H.J. Thomma, Stephen E. Girardin, Bruno Lemaitre
While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, and it is the sole mechanism of host defense in invertebrates and plants. Innate immunity also plays a critical role in maintaining homeostasis
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Hostile bile limits anti-cancer immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Pavitha Parathan, Lisa A. Mielke
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Myeloid C-type lectin receptors in innate immune recognition Immunity (IF 32.4) Pub Date : 2024-04-09 Caetano Reis e Sousa, Sho Yamasaki, Gordon D. Brown
C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and markers of altered self
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Decoding Toll-like receptors: Recent insights and perspectives in innate immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Taro Kawai, Moe Ikegawa, Daisuke Ori, Shizuo Akira
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by recognizing pathogen-associated molecular patterns (PAMPs). TLRs, categorized into cell surface and endosomal subfamilies, recognize diverse PAMPs, and structural elucidation of TLRs and PAMP complexes has revealed their intricate mechanisms
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Physiological functions of RIG-I-like receptors Immunity (IF 32.4) Pub Date : 2024-04-09 Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune responses and have immense physiological importance. In this review, we first summarize the interferon system and innate immunity, which constitute primary and secondary responses. Next, the molecular structure of RLRs and the mechanism of sensing non-self RNA are described. Usually, self RNA is refractory to the RLR;
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DAMPs and DAMP-sensing receptors in inflammation and diseases Immunity (IF 32.4) Pub Date : 2024-04-09 Ming Ma, Wei Jiang, Rongbin Zhou
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules produced in cellular damage or stress, and they can activate the innate immune system. DAMPs contain multiple types of molecules, including nucleic acids, proteins, ions, glycans, and metabolites. Although these endogenous molecules do not trigger immune response under steady-state condition, they may undergo changes in distribution
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New frontiers in the cGAS-STING intracellular DNA-sensing pathway Immunity (IF 32.4) Pub Date : 2024-04-09 Steve Dvorkin, Stephanie Cambier, Hannah E. Volkman, Daniel B. Stetson
The cGAS-STING intracellular DNA-sensing pathway has emerged as a key element of innate antiviral immunity and a promising therapeutic target. The existence of an innate immune sensor that can be activated by any double-stranded DNA (dsDNA) of any origin raises fundamental questions about how cGAS is regulated and how it responds to “foreign” DNA while maintaining tolerance to ubiquitous self-DNA.
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Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance Immunity (IF 32.4) Pub Date : 2024-03-21 Clinton O. Ogega, Nicole E. Skinner, Marta V. Schoenle, Xander E. Wilcox, Nicole Frumento, Desiree A. Wright, Harry T. Paul, Ariadne Sinnis-Bourozikas, Kaitlyn E. Clark, Alexis Figueroa, Pamela J. Bjorkman, Stuart C. Ray, Andrew I. Flyak, Justin R. Bailey
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Epithelial-derived interleukin-23 promotes oral mucosal immunopathology Immunity (IF 32.4) Pub Date : 2024-03-20 Tae Sung Kim, Tomoko Ikeuchi, Vasileios Ionas Theofilou, Drake Winslow Williams, Teresa Greenwell-Wild, Armond June, Emmanuel E. Adade, Lu Li, Loreto Abusleme, Nicolas Dutzan, Yao Yuan, Laurie Brenchley, Nicolas Bouladoux, Yosuke Sakamachi, NIDCD/NIDCR Genomics and Computational Biology Core, Robert J. Palmer Jr., Ramiro Iglesias-Bartolome, Giorgio Trinchieri, Stavros Garantziotis, Yasmine Belkaid
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Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers Immunity (IF 32.4) Pub Date : 2024-03-20 Laila Shehata, Christopher D. Thouvenel, Brian D. Hondowicz, Lucia A. Pew, Gretchen Harms Pritchard, David J. Rawlings, Jinyong Choi, Marion Pepper
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Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants Immunity (IF 32.4) Pub Date : 2024-03-14 Timothy S. Johnston, Shuk Hang Li, Mark M. Painter, Reilly K. Atkinson, Naomi R. Douek, David B. Reeg, Daniel C. Douek, E. John Wherry, Scott E. Hensley
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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans Immunity (IF 32.4) Pub Date : 2024-03-14 M. Alejandra Tortorici, Amin Addetia, Albert J. Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions Immunity (IF 32.4) Pub Date : 2024-03-12 Jingjing Cong, Pianpian Liu, Zili Han, Wei Ying, Chaoliang Li, Yifei Yang, Shuling Wang, Jianbo Yang, Fei Cao, Juntao Shen, Yu Zeng, Yu Bai, Congzhao Zhou, Lilin Ye, Rongbin Zhou, Chunjun Guo, Chunlei Cang, Dennis L. Kasper, Xinyang Song, Lei Dai, Linfeng Sun, Wen Pan, Shu Zhu
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Dual checkpoint T(h1)eamwork makes the anti-cancer dream work Immunity (IF 32.4) Pub Date : 2024-03-12 Alisa Dietl, Anna Ralser, Karin Pelka
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IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging Immunity (IF 32.4) Pub Date : 2024-03-12 Conor M. Finlay, Judith E. Allen
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Predicting plasma cell retention and loss over a lifetime Immunity (IF 32.4) Pub Date : 2024-03-12 Marcus J. Robinson, David M. Tarlinton
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Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases Immunity (IF 32.4) Pub Date : 2024-03-12 Kate E. Lawlor, James M. Murphy, James E. Vince
Diverse inflammatory conditions, from infections to autoimmune disease, are often associated with cellular damage and death. Apoptotic cell death has evolved to minimize its inflammatory potential. By contrast, necrotic cell death via necroptosis and pyroptosis—driven by membrane-damaging MLKL and gasdermins, respectively—can both initiate and propagate inflammatory responses. In this review, we provide
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Complement-ary protection for all ages Immunity (IF 32.4) Pub Date : 2024-03-12 Geongoo Han, Shipra Vaishnava
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The price of P2X7R freedom is neuroinflammation Immunity (IF 32.4) Pub Date : 2024-03-12 Mingqian Fang, Ren Lai
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Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells Immunity (IF 32.4) Pub Date : 2024-03-12 Wei Bu, Ashish Kumar, Nathan L. Board, JungHyun Kim, Kennichi Dowdell, Shu Zhang, Yona Lei, Anna Hostal, Tammy Krogmann, Yanmei Wang, Stefania Pittaluga, Joseph Marcotrigiano, Jeffrey I. Cohen
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with B cell lymphomas. EBV glycoprotein 42 (gp42) binds HLA class II and activates membrane fusion with B cells. We isolated gp42-specific monoclonal antibodies (mAbs), A10 and 4C12, which use distinct mechanisms to neutralize virus infection. mAb A10 was more potent than the only known neutralizing gp42 mAb, F-2-1, in neutralizing
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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer Immunity (IF 32.4) Pub Date : 2024-03-12 Acacia N. Shouse, Kathryn M. LaPorte, Thomas R. Malek
Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells. A critical element for each T cell population is the expression of CD25 (Il2rα), which
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Differentiation route determines the functional outputs of adult megakaryopoiesis Immunity (IF 32.4) Pub Date : 2024-03-05 Jing-Jing Li, Jingkun Liu, Yunqian Evelyn Li, Lin Veronica Chen, Hui Cheng, Yueying Li, Tao Cheng, Qian-Fei Wang, Bo O. Zhou
Emerging evidence has revealed a direct differentiation route from hematopoietic stem cells to megakaryocytes (direct route), in addition to the classical differentiation route through a series of restricted hematopoietic progenitors (stepwise route). This raises the question of the importance of two alternative routes for megakaryopoiesis. Here, we developed fate-mapping systems to distinguish the
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Tuning of plasma cell lifespan by competition explains the longevity and heterogeneity of antibody persistence Immunity (IF 32.4) Pub Date : 2024-03-05 Benjamin D. Simons, Omer Karin
Plasma cells that emerge after infection or vaccination exhibit heterogeneous lifespans; most survive for days to months, whereas others persist for decades, providing antigen-specific long-term protection. We developed a mathematical framework to explore the dynamics of plasma cell removal and its regulation by survival factors. Analyses of antibody persistence following hepatitis A and B and HPV
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CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy Immunity (IF 32.4) Pub Date : 2024-03-04 Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clement
Cancer patients often receive a combination of antibodies targeting programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of-opportunity study in head and neck squamous cell carcinoma (HNSCC) to examine the contribution of anti-CTLA4 to anti-PD-L1 therapy. Single-cell profiling of on- versus pre-treatment biopsies identified T cell expansion as an early
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The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling Immunity (IF 32.4) Pub Date : 2024-03-01 An-Chieh Feng, Brandon J. Thomas, Prabhat K. Purbey, Filipe Menegatti de Melo, Xin Liu, Allison E. Daly, Fei Sun, Jerry Hung-Hao Lo, Lijing Cheng, Michael F. Carey, Philip O. Scumpia, Stephen T. Smale
Inducible nucleosome remodeling at hundreds of latent enhancers and several promoters shapes the transcriptional response to Toll-like receptor 4 (TLR4) signaling in macrophages. We aimed to define the identities of the transcription factors that promote TLR-induced remodeling. An analysis strategy based on ATAC-seq and single-cell ATAC-seq that enriched for genomic regions most likely to undergo remodeling
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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase Immunity (IF 32.4) Pub Date : 2024-03-01 Julia Lederhofer, Yaroslav Tsybovsky, Lam Nguyen, Julie E. Raab, Adrian Creanga, Tyler Stephens, Rebecca A. Gillespie, Hubza Z. Syeda, Brian E. Fisher, Michelle Skertic, Christina Yap, Andrew J. Schaub, Reda Rawi, Peter D. Kwong, Barney S. Graham, Adrian B. McDermott, Sarah F. Andrews, Neil P. King, Masaru Kanekiyo
Continuously evolving influenza viruses cause seasonal epidemics and pose global pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target, our understanding of the NA antigenic landscape still remains incomplete. Here, we describe NA-specific human antibodies that target the underside of the NA globular head domain, inhibit viral propagation of a wide range of human
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Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production Immunity (IF 32.4) Pub Date : 2024-02-28 Munesh K. Harioudh, Joseph Perez, Zhenlu Chong, Sharmila Nair, Lomon So, Kevin D. McCormick, Arundhati Ghosh, Lulu Shao, Rashmi Srivastava, Frank Soveg, Thomas S. Ebert, Maninjay K. Atianand, Veit Hornung, Ram Savan, Michael S. Diamond, Saumendra N. Sarkar
In response to viral infection, how cells balance translational shutdown to limit viral replication and the induction of antiviral components like interferons (IFNs) is not well understood. Moreover, how distinct isoforms of IFN-induced oligoadenylate synthetase 1 (OAS1) contribute to this antiviral response also requires further elucidation. Here, we show that human, but not mouse, OAS1 inhibits SARS-CoV-2
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Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells Immunity (IF 32.4) Pub Date : 2024-02-27 Rui Ding, Xiaoyan Yu, Zhilin Hu, Yu Dong, Haiyan Huang, Yuerong Zhang, Qiaoqiao Han, Zhi-Yu Ni, Ren Zhao, Youqiong Ye, Qiang Zou
RNA splicing is involved in cancer initiation and progression, but how it influences host antitumor immunity in the metabolically abnormal tumor microenvironment (TME) remains unclear. Here, we demonstrate that lactate modulates Foxp3-dependent RNA splicing to maintain the phenotypic and functional status of tumor-infiltrating regulatory T (Treg) cells via CTLA-4. RNA splicing in Treg cells was correlated
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Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety Immunity (IF 32.4) Pub Date : 2024-02-22 Songqiang Huang, Wanting Dong, Xiaoqian Lin, Kangtai Xu, Kun Li, Siping Xiong, Zilong Wang, Xiaowei Nie, Jin-Song Bian
Na/K-ATPase (NKA) plays an important role in the central nervous system. However, little is known about its function in the microglia. Here, we found that NKAα1 forms a complex with the purinergic P2X7 receptor (P2X7R), an adenosine 5′-triphosphate (ATP)-gated ion channel, under physiological conditions. Chronic stress or treatment with lipopolysaccharide plus ATP decreased the membrane expression
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SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase Immunity (IF 32.4) Pub Date : 2024-02-22 Komal Srivastava, Juan Manuel Carreño, Charles Gleason, Brian Monahan, Gagandeep Singh, Anass Abbad, Johnstone Tcheou, Ariel Raskin, Giulio Kleiner, Harm van Bakel, Emilia Mia Sordillo, PARIS Study Group, Hala Alshammary, Angela A. Amoako, Dalles Andre, Mahmoud Awawda, Maria C. Bermúdez-González, Katherine F. Beach, Dominika Bielak, Gianna Y. Cai, Rachel L. Chernet, Christian Cognigni, Yuexing Chen
It is thought that mRNA-based vaccine-induced immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies. Here, we analyzed the kinetics and durability of the humoral responses to SARS-CoV-2 infection and vaccination using >8,000 longitudinal samples collected over a 3-year period in New York City. Upon primary immunization, participants
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LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation Immunity (IF 32.4) Pub Date : 2024-02-13 Nicole Joller, Ana C. Anderson, Vijay K. Kuchroo
LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint receptors being harnessed in the clinic. Although initially studied for their roles in restraining T cell responses, intense investigation over the last several years has started to pinpoint the unique functions of these molecules in other immune cell types. Understanding the distinct processes that these receptors regulate across
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Host-microbial crosstalk relies on “tuft” love Immunity (IF 32.4) Pub Date : 2024-02-13 Stefania De Santis, Theresa T. Pizarro
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Immunity as biophysics at the surface of a T cell Immunity (IF 32.4) Pub Date : 2024-02-13 Daniel S. Chen
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Neutrophils are itching to specialize Immunity (IF 32.4) Pub Date : 2024-02-13 Carlos H. Hiroki, Bryan G. Yipp
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A case of too much sugar: Lung DCs flummoxed by flu Immunity (IF 32.4) Pub Date : 2024-02-13 Ying Xi, Tiffany Horng
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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases Immunity (IF 32.4) Pub Date : 2024-02-13 Anna H. Lippert, Christopher Paluch, Meike Gaglioni, Mai T. Vuong, James McColl, Edward Jenkins, Martin Fellermeyer, Joseph Clarke, Sumana Sharma, Sara Moreira da Silva, Billur Akkaya, Consuelo Anzilotti, Sara H. Morgan, Claire F. Jessup, Markus Körbel, Uzi Gileadi, Judith Leitner, Rachel Knox, Mami Chirifu, Jiandong Huo, Susan Yu, Nicole Ashman, Yuan Lui, Ian Wilkinson, Kathrine E. Attfield, Lars
Antibodies can block immune receptor engagement or trigger the receptor machinery to initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically excluding large receptor-type protein tyrosine phosphatases (RPTPs) such as CD45 from sites of receptor engagement. An agonist targeting the costimulatory receptor CD28 produced signals that depended on antibody immobilization
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The diversity, destiny, and memory of DAMs Immunity (IF 32.4) Pub Date : 2024-02-13 Hongbin Li, Ukpong B. Eyo
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks Immunity (IF 32.4) Pub Date : 2024-02-13 Carla A. Jaeger-Ruckstuhl, Yun Lo, Elena Fulton, Olivia G. Waltner, Tamer B. Shabaneh, Sylvain Simon, Pranav V. Muthuraman, Colin E. Correnti, Oliver J. Newsom, Ian A. Engstrom, Sami B. Kanaan, Shruti S. Bhise, Jobelle M.C. Peralta, Raymond Ruff, Jason P. Price, Sylvia M. Stull, Andrew R. Stevens, Grace Bugos, Mitchell G. Kluesner, Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M. Olson
The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8 T (Tn) cells with homotrimeric CD70 on antigen-presenting cells (APCs) is necessary for T cell memory fate determination. Here, we examined CD27 signaling during Tn cell activation and differentiation. In conjunction with T cell receptor (TCR) stimulation, ligation of CD27 by a synthetic trimeric CD70 ligand
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The B7:CD28 family and friends: Unraveling coinhibitory interactions Immunity (IF 32.4) Pub Date : 2024-02-13 Kelly P. Burke, Apoorvi Chaudhri, Gordon J. Freeman, Arlene H. Sharpe
Immune responses must be tightly regulated to ensure both optimal protective immunity and tolerance. Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial inhibitory signals that maintain immune homeostasis, control resolution of inflammation, regulate host defense, and promote tolerance to prevent autoimmunity
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Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision Immunity (IF 32.4) Pub Date : 2024-01-31 Kathleen Abadie, Elisa C. Clark, Rajesh M. Valanparambil, Obinna Ukogu, Wei Yang, Riza M. Daza, Kenneth K.H. Ng, Jumana Fathima, Allan L. Wang, Judong Lee, Tahseen H. Nasti, Avinash Bhandoola, Armita Nourmohammad, Rafi Ahmed, Jay Shendure, Junyue Cao, Hao Yuan Kueh
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Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis Immunity (IF 32.4) Pub Date : 2024-02-02 Thomas M. Savage, Katherine T. Fortson, Kenia de los Santos-Alexis, Angelica Oliveras-Alsina, Mathieu Rouanne, Sarah S. Rae, Jennifer R. Gamarra, Hani Shayya, Adam Kornberg, Renzo Cavero, Fangda Li, Arnold Han, Rebecca A. Haeusler, Julien Adam, Robert F. Schwabe, Nicholas Arpaia
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Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury Immunity (IF 32.4) Pub Date : 2024-02-02 Yangning Lan, Xiaoxuan Zhang, Shaorui Liu, Chen Guo, Yuxiao Jin, Hui Li, Linyixiao Wang, Jinghong Zhao, Yilin Hao, Zhicheng Li, Zhaoyuan Liu, Florent Ginhoux, Qi Xie, Heping Xu, Jie-Min Jia, Danyang He
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Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response Immunity (IF 32.4) Pub Date : 2024-01-31 Nikolai P. Jaschke, Dorit Breining, Maura Hofmann, Sophie Pählig, Ulrike Baschant, Reinhard Oertel, Sofia Traikov, Tatyana Grinenko, Francesco Saettini, Andrea Biondi, Myrto Stylianou, Henrik Bringmann, Cuiling Zhang, Tomomi M. Yoshida, Heike Weidner, Wolfram C. Poller, Filip K. Swirski, Andy Göbel, Lorenz C. Hofbauer, Martina Rauner, Tilman D. Rachner
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An atlas of cells in the human tonsil Immunity (IF 32.4) Pub Date : 2024-01-31 Ramon Massoni-Badosa, Sergio Aguilar-Fernández, Juan C. Nieto, Paula Soler-Vila, Marc Elosua-Bayes, Domenica Marchese, Marta Kulis, Amaia Vilas-Zornoza, Marco Matteo Bühler, Sonal Rashmi, Clara Alsinet, Ginevra Caratù, Catia Moutinho, Sara Ruiz, Patricia Lorden, Giulia Lunazzi, Dolors Colomer, Gerard Frigola, Will Blevins, Lucia Romero-Rivero, Holger Heyn
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A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection Immunity (IF 32.4) Pub Date : 2024-01-30 Naina Gour, Hwan Mee Yong, Aishwarya Magesh, Aishwarya Atakkatan, Felipe Andrade, Stephane Lajoie, Xinzhong Dong
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Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity Immunity (IF 32.4) Pub Date : 2024-01-30 Emily M. Eshleman, Taylor Rice, Crystal Potter, Amanda Waddell, Seika Hashimoto-Hill, Vivienne Woo, Sydney Field, Laura Engleman, Hee-Woong Lim, Michael A. Schumacher, Mark R. Frey, Lee A. Denson, Fred D. Finkelman, Theresa Alenghat
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Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging Immunity (IF 32.4) Pub Date : 2024-01-22 Zhao Zhou, Jingfei Yao, Dongmei Wu, Xun Huang, Yushuang Wang, Xinmeng Li, Qiang Lu, Yifu Qiu
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Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation Immunity (IF 32.4) Pub Date : 2024-01-15 Henry J. Sutton, Xin Gao, Hannah G. Kelly, Brian J. Parker, Mariah Lofgren, Cherrelle Dacon, Deepyan Chatterjee, Robert A. Seder, Joshua Tan, Azza H. Idris, Teresa Neeman, Ian A. Cockburn
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TREMendous microglial effects on neurons Immunity (IF 32.4) Pub Date : 2024-01-09 Xiao-Fen Chen, Guojun Bu
TREM2 is exclusively expressed by microglia in the brain and is strongly associated with Alzheimer’s disease risk. In this issue of Immunity, Tagliatti et al. shed light on a novel role of TREM2 in shaping neuronal bioenergetics during development.
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You are the tumor queen, microbiome fiend, IL-17 Immunity (IF 32.4) Pub Date : 2024-01-09 Jessica A. Jana, Abigail E. Overacre-Delgoffe
The role of IL-17 signaling in cancer remains convoluted due to its role in regulating the gut microbiome. In a recent issue of Cancer Cell, Chandra et al. demonstrate that microbially driven IL-17 signaling promotes tumor growth.
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Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity Immunity (IF 32.4) Pub Date : 2024-01-09 Simone J.C.F.M. Moorlag, Lukas Folkman, Rob ter Horst, Thomas Krausgruber, Daniele Barreca, Linda C. Schuster, Victoria Fife, Vasiliki Matzaraki, Wenchao Li, Stephan Reichl, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Helga Dijkstra, Heidi Lemmers, Bram van Cranenbroek, Esther van Rijssen, Hans J.P.M. Koenen, Irma Joosten, Cheng-Jian Xu, Christoph Bock
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Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB–CD8+ memory T cells and accumulation of type 2 memory T cells Immunity (IF 32.4) Pub Date : 2024-01-09 Marina Terekhova, Amanda Swain, Pavla Bohacova, Ekaterina Aladyeva, Laura Arthur, Anwesha Laha, Denis A. Mogilenko, Samantha Burdess, Vladimir Sukhov, Denis Kleverov, Barbora Echalar, Petr Tsurinov, Roman Chernyatchik, Kamila Husarcikova, Maxim N. Artyomov
Abstract not available