Owing to the progressive development of metal‐organic frameworks (MOFs) synthetic processes and their unique characters associated with the excellent performance‐selectable composition, tunable pore scale, large surface area, and good thermal stability, MOFs have captured the interest and the imagination of an increasing number of scientists working in different fields. In the area of biomedical applications, MOFs are especially involved in sensing, molecular imaging, and drug delivery, with strong contributions to the whole nanomedicine area. Recently, these materials have been scaled down to nanometer sizes with the advancement of chemical synthesis gradually reaching an adjustable level. This review mainly discusses and summarizes the general synthesis, properties, and biomedical applications of nanoscaled MOFs and their composites in biosensing, imaging, and cancer therapy within the latest three years. The remaining challenges and future opportunities in this field, in terms of processing techniques, maximizing composite properties, and prospects for clinical applications, are also indicated.

中文翻译：

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用于生物传感，成像和癌症治疗的纳米级金属有机框架

由于金属有机骨架（MOF）合成工艺的不断发展及其与出色的性能选择组成，可调节的孔径，大表面积和良好的热稳定性相关的独特特征，MOF引起了人们的兴趣和想象力越来越多的科学家从事不同领域的研究。在生物医学应用领域，MOF特别涉及传感，分子成像和药物递送，对整个纳米医学领域做出了巨大贡献。近来，随着化学合成的进展逐渐达到可调节的水平，这些材料已被缩小到纳米尺寸。这篇评论主要讨论和总结了一般的综合，性质，纳米MOF及其复合材料在最近三年内在生物传感，成像和癌症治疗中的应用以及在生物医学上的应用。还指出了该领域的剩余挑战和未来机会，包括加工技术，最大限度地提高复合材料的性能以及临床应用前景。