Prosopis juliflora (Fabaceae) is a small perennial tree used as human food and livestock feed for thousands of years in arid and semi-arid regions worldwide. This study was performed to investigate the in vivo antimalarial activity of alkaloid-enriched extracts and pure alkaloidal constituents of Prosopis juliflora in a murine model. Alkaloid-enriched extracts from leaves (FACB) and pods (BCE) of P. juliflora, as well as FACB pure constituents (as formate salts), were obtained and assayed against Plasmodium berghei NK65 infection in mice via oral administration. FACB and BCE exhibited a remarkable in vivo antimalarial activity with little parasitemia inhibition at the 2 mg/kg dose. Additionally, julifloridine was weakly active, but juliprosopine caused a parasitemia inhibition at the 2 mg/kg dose similar to that observed for chloroquine at 50 mg/kg. This study reports for the first time the in vivo antimalarial activity of julifloridine, juliprosopine and alkaloid-enriched extracts from P. juliflora (Fabaceae).

鸢尾（Proceops juliflora）是一种多年生小树，在世界各地的干旱和半干旱地区用作人类的食物和牲畜饲料已有数千年的历史。进行这项研究的目的是在小鼠模型中研究富含生物碱的提取物和朱Pro Prosopis juliflora的纯生物碱成分的体内抗疟疾活性。从叶（FACB）和荚（BCE）生物碱富集提取物P. juliflora，以及FACB纯组分（如甲酸盐），获得并分析对伯氏疟原虫通过口服给药在小鼠中NK65感染。FACB和BCE在体内表现出色在2 mg / kg剂量下几乎没有寄生虫抑制作用的抗疟疾活性。此外，朱利弗洛定的活性较弱，但朱利普索平在2 mg / kg的剂量下引起的寄生虫病抑制作用类似于在50 mg / kg的氯喹所观察到的剂量。这项研究首次报道了来自胡杨假单胞菌（豆科）的胡芦丁，胡芦品碱和生物碱富集提取物的体内抗疟活性。