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Patterning of Structurally Anisotropic Composite Hydrogel Sheets
Biomacromolecules ( IF 6.2 ) Pub Date : 2018-03-05 00:00:00 , DOI: 10.1021/acs.biomac.8b00100
Elisabeth Prince 1 , Moien Alizadehgiashi 1 , Melissa Campbell 1 , Nancy Khuu 1 , Alexandra Albulescu 1 , Kevin De France 2 , Dimitrije Ratkov 1 , Yunfeng Li 1 , Todd Hoare 2 , Eugenia Kumacheva 1, 3, 4
Affiliation  

Compositional and structural patterns play a crucial role in the function of many biological tissues. In the present work, for nanofibrillar hydrogels formed by chemically cross-linked cellulose nanocrystals (CNC) and gelatin, we report a microextrusion-based 3D printing method to generate structurally anisotropic hydrogel sheets with CNCs aligned in the direction of extrusion. We prepared hydrogels with a uniform composition, as well as hydrogels with two different types of compositional gradients. In the first type of gradient hydrogel, the composition of the sheet varied parallel to the direction of CNC alignment. In the second hydrogel type, the composition of the sheet changed orthogonally to the direction of CNC alignment. The hydrogels exhibited gradients in structure, mechanical properties, and permeability, all governed by the compositional patterns, as well as cytocompatibility. These hydrogels have promising applications for both fundamental research and for tissue engineering and regenerative medicine.

中文翻译:

结构各向异性复合水凝胶片的图案化

组成和结构模式在许多生物组织的功能中起着至关重要的作用。在当前的工作中,对于由化学交联的纤维素纳米晶体(CNC)和明胶形成的纳米原纤维水凝胶,我们报告了一种基于微挤出的3D打印方法,该方法可生成结构各向异性的水凝胶片材,其中的CNC沿挤出方向排列。我们制备了具有均匀组成的水凝胶,以及具有两种不同类型的组成梯度的水凝胶。在第一种类型的梯度水凝胶中,片材的组成平行于CNC对齐的方向而变化。在第二种水凝胶类型中,片材的组成与CNC排列方向正交。水凝胶在结构,机械性能和渗透性方面表现出梯度,所有这些都由组成模式以及细胞相容性决定。这些水凝胶在基础研究以及组织工程和再生医学中都具有广阔的应用前景。
更新日期:2018-03-05
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