A simple and very sensitive electrochemical sensor for the detection of uric acid (UA) has been developed based on polyaniline (PANI) merged into a silver-doped iron oxide (Ag–Fe₂O₃) nanocomposite-modified glassy carbon electrode. The synthesized ternary composite material (Ag–Fe₂O₃@PANI) was characterized by UV–visible spectroscopy, Fourier transform infrared spectroscopy, energy-dispersive X-ray, High-resolution transmission electron microscopy, X-ray diffraction, and thermo gravimetric analysis analyses. The nanocomposite-modified electrode shows an exceptional electrocatalytic activity and reversibility to the oxidation of UA in a 0.1 M phosphate buffer solution (pH 7.0) compared to those in PANI and Ag–Fe₂O₃. The detection limit of UA is found to be 102 pM with a linear dynamic range of 0.001–0.900 μM. The fabricated UA sensor also exhibits good selectivity, reproducibility, and long-time stability. The limit of detection and linear range attained for the synthesized composite are much greater compared to those of any other composite materials reported in the literature. The proposed method has been successfully applied for the selective detection of UA in various real samples such as human serum and urine with good recoveries. This platform that assimilates such electrocatalytic ternary nanocomposite with high performance can be widely employed for fabricating diverse sensors.

中文翻译：

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掺杂银的氧化铁纳米复合材料与聚苯胺结合的新型电化学传感器及其在人血液和尿液样品中微摩尔级尿酸检测中的应用

基于聚苯胺（PANI）并已将其掺入掺银的氧化铁（Ag-Fe ₂ O ₃）纳米复合改性玻璃碳电极中，开发了一种用于检测尿酸（UA）的简单且非常灵敏的电化学传感器。合成的三元复合材料（Ag-Fe ₂ O ₃ @PANI）的特征在于紫外可见光谱，傅立叶变换红外光谱，能量色散X射线，高分辨率透射电子显微镜，X射线衍射和热重分析法。分析分析。与PANI和Ag-Fe ₂相比，纳米复合材料修饰的电极在0.1 M磷酸盐缓冲溶液（pH 7.0）中显示出优异的电催化活性和UA氧化的可逆性。O ₃。UA的检出限为102 pM，线性动态范围为0.001–0.900μM。制成的UA传感器还具有良好的选择性，可重复性和长期稳定性。与文献中报道的任何其他复合材料相比，合成复合材料的检测极限和线性范围要大得多。所提出的方法已成功地用于选择性检测各种真实样品（如人血清和尿液）中的UA，并具有良好的回收率。具有高性能同化这种电催化三元纳米复合材料的平台可广泛用于制造各种传感器。